2hkk Summary


Carbonic anhydrase activators: Solution and X-ray crystallography for the interaction of andrenaline with various carbonic anhydrase isoforms

The structure was published by Temperini, C., Innocenti, A., Scozzafava, A., Mastrolorenzo, A., and Supuran, C.T., in 2007 in a paper entitled "Carbonic anhydrase activators: L-Adrenaline plugs the active site entrance of isozyme II, activating better isoforms I, IV, VA, VII, and XIV." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 255 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (P00918) cytosolsearch cytoplasmsearch apical part of cellsearch plasma membranesearch myelin sheathsearch extracellular vesicular exosomesearch microvillussearch membranesearch extracellular spacesearch axonsearch basolateral plasma membranesearch carbonate dehydratase activitysearch zinc ion bindingsearch protein bindingsearch lyase activitysearch metal ion bindingsearch bicarbonate transportsearch morphogenesis of an epitheliumsearch positive regulation of osteoclast differentiationsearch positive regulation of cellular pH reductionsearch positive regulation of dipeptide transmembrane transportsearch one-carbon metabolic processsearch regulation of intracellular pHsearch small molecule metabolic processsearch response to pHsearch regulation of anion transportsearch response to estrogensearch secretionsearch response to organic substancesearch odontogenesis of dentin-containing toothsearch positive regulation of bone resorptionsearch kidney developmentsearch positive regulation of synaptic transmission, GABAergicsearch regulation of chloride transportsearch response to zinc ionsearch angiotensin-activated signaling pathwaysearch response to steroid hormonesearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch