› 2hj8

Solution NMR

Solution NMR structure of the C-terminal domain of the interferon alpha-inducible ISG15 protein from Homo sapiens. Northeast Structural Genomics target HR2873B

Released:
DOI: 10.2210/pdb2hj8/pdb
PDB entry 2hj8 coloured by chain, ensemble of 20 models, front view.
PDB entry 2hj8 coloured by chain, ensemble of 20 models, side view.
PDB entry 2hj8 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Aramini JM, Ho CK, Yin C, Cunningham K, Janjua H, Ma L-C, Xiao R, Acton TB, Montelione GT, Northeast Structural Genomics Consortium (NESG)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138564 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ubiquitin-like protein ISG15 Chain: A
Molecule details ›
Chain: A
Length: 88 amino acids
Theoretical weight: 10.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05161 (Residues: 79-157; Coverage: 48%)
Gene names: G1P2, ISG15, UCRP
Sequence domains: Ubiquitin family
Structure domains: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

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