2hio Summary

pdbe.org/2hio
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HISTONE OCTAMER (CHICKEN), CHROMOSOMAL PROTEIN

The structure was published by Arents, G., Burlingame, R.W., Wang, B.C., Love, W.E., and Moudrianakis, E.N., in 1991 in a paper entitled "The nucleosomal core histone octamer at 3.1 A resolution: a tripartite protein assembly and a left-handed superhelix." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.1 Å and deposited in 1999.

The experimental data on which the structure is based was not deposited.

This entry contains 4 copies of 4 unique biopolymers (complete list).

The molecule most likely forms heterooctamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (HISTONE H2A) P02263 (2-129) (H2A4_CHICK)search Gallus gallussearch 99% 128 78%
B PROTEIN (HISTONE H2B) P0C1H5 (2-126) (H2B7_CHICK)search Gallus gallussearch 99% 125 72%
C PROTEIN (HISTONE H3) P84229 (1-136) (H32_CHICK)search Gallus gallussearch 99% 136 68%
D PROTEIN (HISTONE H4) P62801 (1-103) (H4_CHICK)search Gallus gallussearch 99% 103 75%


This entry contains 4 unique UniProt proteins:

UniProt accession Name Organism PDB
P02263 (2 - 129) PROTEIN (HISTONE H2A) Gallus gallus
P0C1H5 (2 - 126) PROTEIN (HISTONE H2B) Gallus gallus
P84229 (1 - 136) PROTEIN (HISTONE H3) Gallus gallus
P62801 (1 - 103) PROTEIN (HISTONE H4) Gallus gallus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P02263) Nucleosome core histonessearch Histone, subunit Asearch PF00125: Core histone H2A/H2B/H3/H4search
B (P0C1H5) Nucleosome core histonessearch Histone, subunit Asearch PF00125: Core histone H2A/H2B/H3/H4search
C (P84229) Nucleosome core histonessearch Histone, subunit Asearch PF00125: Core histone H2A/H2B/H3/H4search
D (P62801) Nucleosome core histonessearch Histone, subunit Asearch PF00125: Core histone H2A/H2B/H3/H4search

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P02263) protein heterodimerization activitysearch DNA bindingsearch nucleussearch chromosomesearch nucleosomesearch
B (P0C1H5) protein heterodimerization activitysearch DNA bindingsearch nucleussearch nucleosomesearch chromosomesearch lipid particlesearch NuA4 histone acetyltransferase complexsearch
C (P84229) DNA bindingsearch protein heterodimerization activitysearch nucleosomesearch extracellular vesicular exosomesearch chromosomesearch nucleussearch
D (P62801) DNA bindingsearch poly(A) RNA bindingsearch protein heterodimerization activitysearch nucleussearch nucleoplasmsearch nucleosomesearch chromosomesearch extracellular vesicular exosomesearch nuclear chromosomesearch protein complexsearch DNA replication-independent nucleosome assemblysearch nucleosome assemblysearch DNA replication-dependent nucleosome assemblysearch negative regulation of megakaryocyte differentiationsearch

Chain InterPro annotation
A Histone H2Asearch Histone coresearch Histone-foldsearch
B Histone H2Bsearch Histone coresearch Histone-foldsearch
C Histone H3/CENP-Asearch Histone coresearch Histone-foldsearch
D Histone H4search Histone coresearch Histone-foldsearch Histone H4, conserved sitesearch