2hi3 Summary


Solution structure of the homeodomain-only protein HOP

The structure was published by Kook, H., Yung, W.W., Simpson, R.J., et al., Yin, Z., Epstein, J.A., and Mackay, J.P., in 2006 in a paper entitled "Analysis of the structure and function of the transcriptional coregulator HOP" (abstract).

The structure was determined using NMR spectroscopy and deposited in 2006.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of Homeodomain-only protein. This molecule has the UniProt identifier Q8R1H0 (HOP_MOUSE)search. The sample contained 73 residues which is 100% of the natural sequence. Out of 73 residues 73 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Homeodomain-only protein Q8R1H0 (1-73) (HOP_MOUSE)search Mus musculussearch 100% 73 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q8R1H0 (1 - 73) Homeodomain-only protein Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q8R1H0) Homeodomainsearch Homeodomain-likesearch PF00046: Homeobox domainsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (Q8R1H0) sequence-specific DNA binding transcription factor activitysearch protein bindingsearch DNA bindingsearch sequence-specific DNA bindingsearch nucleussearch cytoplasmsearch heart developmentsearch regulation of transcription, DNA-templatedsearch positive regulation of skeletal muscle tissue regenerationsearch positive regulation of striated muscle cell differentiationsearch trophectodermal cell differentiationsearch negative regulation of transcription from RNA polymerase II promotersearch transcription, DNA-templatedsearch negative regulation of cell differentiationsearch histone deacetylationsearch lung alveolus developmentsearch multicellular organismal developmentsearch regulation of heart contractionsearch regulation of protein bindingsearch

Chain InterPro annotation
A Homeobox domainsearch Homeodomain-likesearch