2hhe Summary

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OXYGEN AFFINITY MODULATION BY THE N-TERMINI OF THE BETA CHAINS IN HUMAN AND BOVINE HEMOGLOBIN

The structure was published by Fronticelli, C., Pechik, I., Brinigar, W.S., Kowalczyk, J., and Gilliland, G.L., in 1994 in a paper entitled "Chloride ion independence of the Bohr effect in a mutant human hemoglobin beta (V1M+H2deleted)." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 1994.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN (DEOXY) (ALPHA CHAIN) and HEMOGLOBIN (DEOXY) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN (DEOXY) (BETA CHAIN) P68871 (4-147) (HBB_HUMAN)search Homo sapienssearch 98% 145 100%
D HEMOGLOBIN (DEOXY) (BETA CHAIN) P68871 (4-147) (HBB_HUMAN)search Homo sapienssearch 98% 145 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN (DEOXY) (ALPHA CHAIN) Homo sapiens
P68871 (4 - 147) HEMOGLOBIN (DEOXY) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, C (P69905) oxygen transportsearch bicarbonate transportsearch transportsearch oxidation-reduction processsearch receptor-mediated endocytosissearch protein heterooligomerizationsearch response to hydrogen peroxidesearch hydrogen peroxide catabolic processsearch positive regulation of cell deathsearch small molecule metabolic processsearch hemoglobin complexsearch endocytic vesicle lumensearch extracellular vesicular exosomesearch membranesearch extracellular regionsearch cytosolic small ribosomal subunitsearch haptoglobin-hemoglobin complexsearch blood microparticlesearch cytosolsearch metal ion bindingsearch heme bindingsearch protein bindingsearch iron ion bindingsearch oxygen bindingsearch peroxidase activitysearch haptoglobin bindingsearch oxygen transporter activitysearch
B, D (P68871) platelet aggregationsearch oxygen transportsearch hydrogen peroxide catabolic processsearch bicarbonate transportsearch transportsearch positive regulation of nitric oxide biosynthetic processsearch protein heterooligomerizationsearch renal absorptionsearch small molecule metabolic processsearch oxidation-reduction processsearch blood coagulationsearch regulation of blood pressuresearch positive regulation of cell deathsearch receptor-mediated endocytosissearch nitric oxide transportsearch response to hydrogen peroxidesearch regulation of blood vessel sizesearch extracellular vesicular exosomesearch cytosolsearch extracellular regionsearch haptoglobin-hemoglobin complexsearch blood microparticlesearch hemoglobin complexsearch endocytic vesicle lumensearch peroxidase activitysearch protein bindingsearch haptoglobin bindingsearch oxygen bindingsearch iron ion bindingsearch heme bindingsearch oxygen transporter activitysearch metal ion bindingsearch hemoglobin bindingsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch