2hhd Summary

pdbe.org/2hhd
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OXYGEN AFFINITY MODULATION BY THE N-TERMINI OF THE BETA-CHAINS IN HUMAN AND BOVINE HEMOGLOBIN

The structure was published by Pechik, I., Ji, X., Fidelis, K., et al., Brinigar, W.S., Fronticelli, C., and Gilliland, G.L., in 1996 in a paper entitled "Crystallographic, molecular modeling, and biophysical characterization of the valine beta 67 (E11)-->threonine variant of hemoglobin." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 1994.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN (DEOXY) (ALPHA CHAIN) and HEMOGLOBIN (DEOXY) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN (DEOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN (DEOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN (DEOXY) (ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) HEMOGLOBIN (DEOXY) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, C (P69905) oxygen transportsearch positive regulation of cell deathsearch protein heterooligomerizationsearch bicarbonate transportsearch oxidation-reduction processsearch hydrogen peroxide catabolic processsearch response to hydrogen peroxidesearch transportsearch small molecule metabolic processsearch hemoglobin complexsearch extracellular regionsearch blood microparticlesearch extracellular vesicular exosomesearch cytosolsearch membranesearch cytosolic small ribosomal subunitsearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch haptoglobin bindingsearch oxygen transporter activitysearch protein bindingsearch heme bindingsearch iron ion bindingsearch oxygen bindingsearch metal ion bindingsearch peroxidase activitysearch
B, D (P68871) oxygen transportsearch renal absorptionsearch nitric oxide transportsearch positive regulation of cell deathsearch positive regulation of nitric oxide biosynthetic processsearch bicarbonate transportsearch oxidation-reduction processsearch hydrogen peroxide catabolic processsearch regulation of blood pressuresearch blood coagulationsearch platelet aggregationsearch small molecule metabolic processsearch regulation of blood vessel sizesearch response to hydrogen peroxidesearch transportsearch protein heterooligomerizationsearch hemoglobin complexsearch cytosolsearch endocytic vesicle lumensearch extracellular regionsearch blood microparticlesearch haptoglobin-hemoglobin complexsearch extracellular vesicular exosomesearch protein bindingsearch haptoglobin bindingsearch oxygen transporter activitysearch iron ion bindingsearch heme bindingsearch oxygen bindingsearch metal ion bindingsearch hemoglobin bindingsearch peroxidase activitysearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch