2hhd Summary

pdbe.org/2hhd
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OXYGEN AFFINITY MODULATION BY THE N-TERMINI OF THE BETA-CHAINS IN HUMAN AND BOVINE HEMOGLOBIN

The structure was published by Pechik, I., Ji, X., Fidelis, K., et al., Brinigar, W.S., Fronticelli, C., and Gilliland, G.L., in 1996 in a paper entitled "Crystallographic, molecular modeling, and biophysical characterization of the valine beta 67 (E11)-->threonine variant of hemoglobin." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 1994.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN (DEOXY) (ALPHA CHAIN) and HEMOGLOBIN (DEOXY) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN (DEOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN (DEOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN (DEOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN (DEOXY) (ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) HEMOGLOBIN (DEOXY) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, C (P69905) oxygen transportsearch protein heterooligomerizationsearch bicarbonate transportsearch receptor-mediated endocytosissearch hydrogen peroxide catabolic processsearch response to hydrogen peroxidesearch oxidation-reduction processsearch small molecule metabolic processsearch transportsearch positive regulation of cell deathsearch heme bindingsearch protein bindingsearch oxygen transporter activitysearch peroxidase activitysearch metal ion bindingsearch iron ion bindingsearch haptoglobin bindingsearch oxygen bindingsearch hemoglobin complexsearch membranesearch cytosolsearch cytosolic small ribosomal subunitsearch extracellular exosomesearch blood microparticlesearch haptoglobin-hemoglobin complexsearch extracellular regionsearch endocytic vesicle lumensearch
B, D (P68871) bicarbonate transportsearch oxygen transportsearch oxidation-reduction processsearch hydrogen peroxide catabolic processsearch transportsearch blood coagulationsearch receptor-mediated endocytosissearch platelet aggregationsearch response to hydrogen peroxidesearch renal absorptionsearch small molecule metabolic processsearch protein heterooligomerizationsearch regulation of blood vessel sizesearch regulation of blood pressuresearch nitric oxide transportsearch positive regulation of cell deathsearch positive regulation of nitric oxide biosynthetic processsearch heme bindingsearch oxygen bindingsearch protein bindingsearch oxygen transporter activitysearch hemoglobin bindingsearch iron ion bindingsearch metal ion bindingsearch peroxidase activitysearch haptoglobin bindingsearch extracellular regionsearch blood microparticlesearch haptoglobin-hemoglobin complexsearch hemoglobin complexsearch extracellular exosomesearch cytosolsearch endocytic vesicle lumensearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch