2hfp Summary


Crystal Structure of PPAR Gamma with N-sulfonyl-2-indole carboxamide ligands

The structure was published by Hopkins, C.R., O'neil, S.V., Laufersweiler, M.C., et al., Roesgen, J.T., Richardson, E., and Demuth Jr., T.P., in 2006 in a paper entitled "Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-gamma binding agents with potential application to the treatment of osteoporosis." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Peroxisome proliferator-activated receptor gamma and SRC Peptide Fragment.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Peroxisome proliferator-activated receptor gamma P37231 (234-505) (PPARG_HUMAN)search Homo sapienssearch < 90% 282 96%
B SRC Peptide Fragment Q15788 (680-700) (NCOA1_HUMAN)search Homo sapienssearch < 90% 21 80%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P37231 (234 - 505) Peroxisome proliferator-activated receptor gamma Homo sapiens
Q15788 (680 - 700) SRC Peptide Fragment

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch
B Steroid receptor coactivatorsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P37231) DNA bindingsearch sequence-specific DNA binding transcription factor activitysearch steroid hormone receptor activitysearch ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitysearch nucleussearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch

Chain InterPro annotation
A Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Peroxisome proliferator-activated receptorsearch Nuclear hormone receptor, ligand-bindingsearch
B Nuclear receptor coactivator Src-1search Steroid receptor coactivatorsearch