Crystal Structure of PPAR Gamma with N-sulfonyl-2-indole carboxamide ligands
The structure was published by Hopkins, C.R., O'neil, S.V., Laufersweiler, M.C., et al., Roesgen, J.T., Richardson, E., and Demuth Jr., T.P., in 2006 in a paper entitled "Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-gamma binding agents with potential application to the treatment of osteoporosis." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2006.
The experimental data on which the structure is based was also deposited.
This PDB entry contains a complex of 2 biomacromolecules, namely Peroxisome proliferator-activated receptor gamma and SRC Peptide Fragment.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule most likely forms heterodimers.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 2 unique UniProt proteins: