Structure analysis

Crystal Structure of PPAR Gamma with N-sulfonyl-2-indole carboxamide ligands

X-ray diffraction
2Å resolution
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero dimer
Accessible surface area: 13855.18 Å2
Buried surface area: 3702.49 Å2
Dissociation area: 680.98 Å2
Dissociation energy (ΔGdiss): 2.34 kcal/mol
Dissociation entropy (TΔSdiss): 8.54 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-153375
Complex Portal ID: CPX-711

Macromolecules

Chain: A
Length: 282 amino acids
Theoretical weight: 32.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P37231 (Residues: 234-505; Coverage: 54%)
Gene names: NR1C3, PPARG
Pfam: Ligand-binding domain of nuclear hormone receptor
InterPro:
CATH: Retinoid X Receptor
SCOP: Nuclear receptor ligand-binding domain

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Chain: B
Length: 21 amino acids
Theoretical weight: 2.43 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15788 (Residues: 680-700; Coverage: 2%)
Gene names: BHLHE74, NCOA1, SRC1
InterPro: Nuclear receptor coactivator, receptor-binding domain

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