2hdd Summary



The structure was published by Tucker-Kellogg, L., Rould, M.A., Chambers, K.A., Ades, S.E., Sauer, R.T., and Pabo, C.O., in 1997 in a paper entitled "Engrailed (Gln50-->Lys) homeodomain-DNA complex at 1.9 A resolution: structural basis for enhanced affinity and altered specificity." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 1998.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely DNA (5'-D(*TP*TP*TP*TP*GP*CP*CP*AP*TP*GP*TP*AP*AP*TP*CP*CP*C P*CP*GP*GP*A)-3'), DNA (5'-D(*AP*TP*CP*CP*GP*GP*GP*GP*AP*TP*TP*AP*CP*AP*TP*GP*G P*CP*AP*AP*A)-3'), and PROTEIN (ENGRAILED HOMEODOMAIN Q50K).

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (ENGRAILED HOMEODOMAIN Q50K) P02836 (454-512) (HMEN_DROME)search Drosophila melanogastersearch < 90% 61 91%
B PROTEIN (ENGRAILED HOMEODOMAIN Q50K) P02836 (454-512) (HMEN_DROME)search Drosophila melanogastersearch < 90% 61 91%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P02836 (454 - 512) PROTEIN (ENGRAILED HOMEODOMAIN Q50K) Drosophila melanogaster

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Homeodomainsearch Homeodomain-likesearch Homeobox domainsearch, Engrailed homeobox C-terminal signature domainsearch

Chain ID Biological process (GO) Molecular function (GO)
A, B (P02836) regulation of transcription, DNA-templatedsearch DNA bindingsearch sequence-specific DNA bindingsearch

Chain InterPro annotation
A, B Helix-turn-helix motifsearch Homeobox domainsearch Homeodomain-likesearch Homeobox, conserved sitesearch Homeodomain, metazoasearch