2hco Summary

pdbe.org/2hco
spacer

THE STRUCTURE OF HUMAN CARBONMONOXY HAEMOGLOBIN AT 2.7 ANGSTROMS RESOLUTION

The structure was published by Baldwin, J.M., in 1980 in a paper entitled "The structure of human carbonmonoxy haemoglobin at 2.7 A resolution." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.7 Å and deposited in 1979.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN (CARBONMONOXY) (ALPHA CHAIN) and HEMOGLOBIN (CARBONMONOXY) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN (CARBONMONOXY) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN (CARBONMONOXY) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN (CARBONMONOXY) (ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) HEMOGLOBIN (CARBONMONOXY) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P69905) hemoglobin complexsearch endocytic vesicle lumensearch extracellular regionsearch cytosolsearch membranesearch extracellular exosomesearch blood microparticlesearch cytosolic small ribosomal subunitsearch haptoglobin-hemoglobin complexsearch oxygen transportsearch protein heterooligomerizationsearch oxidation-reduction processsearch hydrogen peroxide catabolic processsearch receptor-mediated endocytosissearch bicarbonate transportsearch transportsearch response to hydrogen peroxidesearch small molecule metabolic processsearch positive regulation of cell deathsearch iron ion bindingsearch heme bindingsearch haptoglobin bindingsearch protein bindingsearch peroxidase activitysearch metal ion bindingsearch oxygen bindingsearch oxygen transporter activitysearch
B (P68871) hemoglobin complexsearch extracellular regionsearch endocytic vesicle lumensearch extracellular exosomesearch cytosolsearch haptoglobin-hemoglobin complexsearch blood microparticlesearch bicarbonate transportsearch oxygen transportsearch response to hydrogen peroxidesearch blood coagulationsearch regulation of blood pressuresearch renal absorptionsearch oxidation-reduction processsearch positive regulation of cell deathsearch hydrogen peroxide catabolic processsearch protein heterooligomerizationsearch regulation of blood vessel sizesearch small molecule metabolic processsearch transportsearch receptor-mediated endocytosissearch nitric oxide transportsearch platelet aggregationsearch positive regulation of nitric oxide biosynthetic processsearch heme bindingsearch protein bindingsearch iron ion bindingsearch peroxidase activitysearch oxygen transporter activitysearch oxygen bindingsearch hemoglobin bindingsearch metal ion bindingsearch haptoglobin bindingsearch

Chain InterPro annotation
A Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch