2hck Summary



The structure was published by Sicheri, F., Moarefi, I., and Kuriyan, J., in 1997 in a paper entitled "Crystal structure of the Src family tyrosine kinase Hck." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 1997.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of HEMATOPOETIC CELL KINASE HCK.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMATOPOETIC CELL KINASE HCK P08631 (79-526) (HCK_HUMAN)search Homo sapienssearch < 90% 438 100%
B HEMATOPOETIC CELL KINASE HCK P08631 (79-526) (HCK_HUMAN)search Homo sapienssearch < 90% 438 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P08631 (79 - 526) HEMATOPOETIC CELL KINASE HCK Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B SH3-domainsearch, SH2 domainsearch, Protein kinases, catalytic subunitsearch SH3 Domainssearch, SHC Adaptor Proteinsearch, Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search SH2 domainsearch, SH3 domainsearch, Protein tyrosine kinasesearch

Chain ID Biological process (GO) Molecular function (GO)
A, B (P08631) protein phosphorylationsearch protein kinase activitysearch protein tyrosine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch

Chain InterPro annotation
A, B Protein kinase domainsearch SH2 domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch SH3 domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch