› 2hc0

X-ray diffraction
1.3Å resolution

Structure of HIV protease 6X mutant in complex with AB-2.

Released:
DOI: 10.2210/pdb2hc0/pdb
PDB entry 2hc0 coloured by chain, front view.
PDB entry 2hc0 coloured by chain, side view.
PDB entry 2hc0 coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Entry authors: Heaslet H, Brik A, Lin Y-C, Elder JH, Stout CD

Function and Biology Details

Reaction catalysed: 
Specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190132 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidase A2 domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 99 amino acids
Theoretical weight: 10.75 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9E3M8 (Residues: 1-99; Coverage: 100%)
Gene name: pol
Sequence domains: Retroviral aspartyl protease
Structure domains: Acid Proteases

Ligands and Environments

2 bound ligands:
Ligand BR 12 x BR
Ligand AB2 1 x AB2
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P43
Unit cell:
a: 86.61Å b: 86.61Å c: 33.66Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.161 0.142 0.168
Expression system: Escherichia coli

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