2hbs Summary

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THE HIGH RESOLUTION CRYSTAL STRUCTURE OF DEOXYHEMOGLOBIN S

The structure was published by Harrington, D.J., Adachi, K., and Royer Jr., W.E., in 1997 in a paper entitled "The high resolution crystal structure of deoxyhemoglobin S." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.05 Å and deposited in 1997.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN S.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN S P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN S P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
E HEMOGLOBIN S P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
G HEMOGLOBIN S P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN S P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN S P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
F HEMOGLOBIN S P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
H HEMOGLOBIN S P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN S Homo sapiens
P68871 (2 - 147) HEMOGLOBIN S Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C, E, G (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D, F, H (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, C, E, G (P69905) hemoglobin complexsearch membranesearch extracellular vesicular exosomesearch extracellular regionsearch cytosolsearch cytosolic small ribosomal subunitsearch blood microparticlesearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch iron ion bindingsearch oxygen bindingsearch heme bindingsearch protein bindingsearch metal ion bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch peroxidase activitysearch oxygen transportsearch bicarbonate transportsearch small molecule metabolic processsearch transportsearch protein heterooligomerizationsearch hydrogen peroxide catabolic processsearch response to hydrogen peroxidesearch oxidation-reduction processsearch positive regulation of cell deathsearch
B, D, F, H (P68871) hemoglobin complexsearch endocytic vesicle lumensearch cytosolsearch extracellular vesicular exosomesearch haptoglobin-hemoglobin complexsearch extracellular regionsearch blood microparticlesearch iron ion bindingsearch oxygen bindingsearch heme bindingsearch protein bindingsearch oxygen transporter activitysearch hemoglobin bindingsearch peroxidase activitysearch metal ion bindingsearch haptoglobin bindingsearch oxygen transportsearch hydrogen peroxide catabolic processsearch positive regulation of nitric oxide biosynthetic processsearch oxidation-reduction processsearch bicarbonate transportsearch regulation of blood vessel sizesearch renal absorptionsearch protein heterooligomerizationsearch transportsearch platelet aggregationsearch blood coagulationsearch small molecule metabolic processsearch response to hydrogen peroxidesearch regulation of blood pressuresearch nitric oxide transportsearch positive regulation of cell deathsearch

Chain InterPro annotation
A, C, E, G Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D, F, H Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch