2hbs Summary

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THE HIGH RESOLUTION CRYSTAL STRUCTURE OF DEOXYHEMOGLOBIN S

The structure was published by Harrington, D.J., Adachi, K., and Royer Jr., W.E., in 1997 in a paper entitled "The high resolution crystal structure of deoxyhemoglobin S." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.05 Å and deposited in 1997.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN S.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN S P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C HEMOGLOBIN S P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
E HEMOGLOBIN S P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
G HEMOGLOBIN S P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN S P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D HEMOGLOBIN S P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
F HEMOGLOBIN S P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
H HEMOGLOBIN S P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN S Homo sapiens
P68871 (2 - 147) HEMOGLOBIN S Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C, E, G (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D, F, H (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C, E, G (P69905) iron ion bindingsearch heme bindingsearch metal ion bindingsearch protein bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch oxygen bindingsearch peroxidase activitysearch bicarbonate transportsearch hydrogen peroxide catabolic processsearch response to hydrogen peroxidesearch oxidation-reduction processsearch transportsearch positive regulation of cell deathsearch oxygen transportsearch receptor-mediated endocytosissearch small molecule metabolic processsearch protein heterooligomerizationsearch haptoglobin-hemoglobin complexsearch hemoglobin complexsearch cytosolsearch extracellular regionsearch extracellular vesicular exosomesearch membranesearch cytosolic small ribosomal subunitsearch endocytic vesicle lumensearch blood microparticlesearch
B, D, F, H (P68871) heme bindingsearch oxygen transporter activitysearch protein bindingsearch oxygen bindingsearch haptoglobin bindingsearch iron ion bindingsearch metal ion bindingsearch peroxidase activitysearch hemoglobin bindingsearch oxygen transportsearch transportsearch protein heterooligomerizationsearch blood coagulationsearch platelet aggregationsearch receptor-mediated endocytosissearch small molecule metabolic processsearch bicarbonate transportsearch renal absorptionsearch response to hydrogen peroxidesearch positive regulation of cell deathsearch regulation of blood vessel sizesearch nitric oxide transportsearch hydrogen peroxide catabolic processsearch regulation of blood pressuresearch positive regulation of nitric oxide biosynthetic processsearch oxidation-reduction processsearch blood microparticlesearch cytosolsearch hemoglobin complexsearch extracellular regionsearch extracellular vesicular exosomesearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch

Chain InterPro annotation
A, C, E, G Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D, F, H Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch