2hbj Summary

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Structure of the yeast nuclear exosome component, Rrp6p, reveals an interplay between the active site and the HRDC domain

The structure was published by Midtgaard, S.F., Assenholt, J., Jonstrup, A.T., Van, L.B., Jensen, T.H., and Brodersen, D.E., in 2006 in a paper entitled "Structure of the nuclear exosome component Rrp6p reveals an interplay between the active site and the HRDC domain." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Exosome complex exonuclease RRP6. This molecule has the UniProt identifier Q12149 (RRP6_YEAST)search. The sample contained 410 residues which is < 90% of the natural sequence. Out of 410 residues 390 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Exosome complex exonuclease RRP6 Q12149 (129-536) (RRP6_YEAST)search Saccharomyces cerevisiae S288csearch < 90% 410 95%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q12149 (129 - 536) Exosome complex exonuclease RRP6 Saccharomyces cerevisiae

Chain Structural classification (SCOP) Sequence family (Pfam)
A EXOSC10 HRDC domain-likesearch, DnaQ-like 3'-5' exonucleasesearch HRDC domainsearch, 3'-5' exonucleasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (Q12149) cellular metabolic processsearch nucleobase-containing compound metabolic processsearch nucleic acid bindingsearch nucleotide bindingsearch catalytic activitysearch 3'-5' exonuclease activitysearch intracellularsearch

Chain InterPro annotation
A HRDC domainsearch 3'-5' exonuclease domainsearch HRDC-likesearch Ribonuclease H-like domainsearch