2hbh Summary


Crystal structure of Vitamin D nuclear receptor ligand binding domain bound to a locked side-chain analog of calcitriol and SRC-1 peptide

The structure was published by Rochel, N., Hourai, S., Perez-Garcia, X., Rumbo, A., Mourino, A., and Moras, D., in 2007 in a paper entitled "Crystal structure of the vitamin D nuclear receptor ligand binding domain in complex with a locked side chain analog of calcitriol" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.65 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Vitamin D receptor and SRC-1 from Nuclear receptor coactivator 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Vitamin D receptor Q9PTN2 (156-453) (VDRA_DANRE)search Danio reriosearch < 90% 302 79%
B SRC-1 from Nuclear receptor coactivator 1 Q15788 (686-700) (NCOA1_HUMAN)search Homo sapienssearch < 90% 15 66%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q9PTN2 (156 - 453) Vitamin D receptor Danio rerio
Q15788 (686 - 700) SRC-1 from Nuclear receptor coactivator 1

Chain Structural classification (CATH) Sequence family (Pfam)
A Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch
B Steroid receptor coactivatorsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (Q9PTN2) nucleussearch calcitriol receptor activitysearch sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch steroid hormone receptor activitysearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch

Chain InterPro annotation
A Vitamin D receptorsearch Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch
B Nuclear receptor coactivator Src-1search Epsin-like, N-terminalsearch Steroid receptor coactivatorsearch