2hbf Summary

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HIGH RESOLUTION X-RAY STRUCTURES OF MYOGLOBIN-AND HEMOGLOBIN-ALKYL ISOCYANIDE COMPLEXES

The structure was published by Johnson, K.A., in 1993 in a paper entitled "High Resolution X-Ray Structures of Myoglobin-and Hemoglobin-Alkyl Isocyanide Complexes" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 1994.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN A (N-PROPYL ISOCYANIDE) (ALPHA CHAIN) and HEMOGLOBIN A (N-PROPYL ISOCYANIDE) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN A (N-PROPYL ISOCYANIDE) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN A (N-PROPYL ISOCYANIDE) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN A (N-PROPYL ISOCYANIDE) (ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) HEMOGLOBIN A (N-PROPYL ISOCYANIDE) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P69905) oxygen bindingsearch iron ion bindingsearch heme bindingsearch protein bindingsearch metal ion bindingsearch peroxidase activitysearch oxygen transporter activitysearch haptoglobin bindingsearch extracellular vesicular exosomesearch hemoglobin complexsearch extracellular regionsearch endocytic vesicle lumensearch membranesearch cytosolsearch haptoglobin-hemoglobin complexsearch cytosolic small ribosomal subunitsearch blood microparticlesearch receptor-mediated endocytosissearch bicarbonate transportsearch response to hydrogen peroxidesearch positive regulation of cell deathsearch oxygen transportsearch small molecule metabolic processsearch transportsearch oxidation-reduction processsearch hydrogen peroxide catabolic processsearch protein heterooligomerizationsearch
B (P68871) iron ion bindingsearch protein bindingsearch oxygen transporter activitysearch hemoglobin bindingsearch heme bindingsearch oxygen bindingsearch peroxidase activitysearch metal ion bindingsearch haptoglobin bindingsearch haptoglobin-hemoglobin complexsearch extracellular vesicular exosomesearch extracellular regionsearch hemoglobin complexsearch endocytic vesicle lumensearch cytosolsearch blood microparticlesearch oxygen transportsearch nitric oxide transportsearch regulation of blood pressuresearch bicarbonate transportsearch regulation of blood vessel sizesearch renal absorptionsearch protein heterooligomerizationsearch platelet aggregationsearch transportsearch small molecule metabolic processsearch oxidation-reduction processsearch response to hydrogen peroxidesearch blood coagulationsearch positive regulation of nitric oxide biosynthetic processsearch hydrogen peroxide catabolic processsearch receptor-mediated endocytosissearch positive regulation of cell deathsearch

Chain InterPro annotation
A Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch