2hbf Summary

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HIGH RESOLUTION X-RAY STRUCTURES OF MYOGLOBIN-AND HEMOGLOBIN-ALKYL ISOCYANIDE COMPLEXES

The structure was published by Johnson, K.A., in 1993 in a paper entitled "High Resolution X-Ray Structures of Myoglobin-and Hemoglobin-Alkyl Isocyanide Complexes" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 1994.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN A (N-PROPYL ISOCYANIDE) (ALPHA CHAIN) and HEMOGLOBIN A (N-PROPYL ISOCYANIDE) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN A (N-PROPYL ISOCYANIDE) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN A (N-PROPYL ISOCYANIDE) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN A (N-PROPYL ISOCYANIDE) (ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) HEMOGLOBIN A (N-PROPYL ISOCYANIDE) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P69905) oxygen transportsearch small molecule metabolic processsearch bicarbonate transportsearch oxidation-reduction processsearch transportsearch positive regulation of cell deathsearch hydrogen peroxide catabolic processsearch protein heterooligomerizationsearch response to hydrogen peroxidesearch oxygen bindingsearch iron ion bindingsearch oxygen transporter activitysearch protein bindingsearch haptoglobin bindingsearch heme bindingsearch metal ion bindingsearch peroxidase activitysearch hemoglobin complexsearch haptoglobin-hemoglobin complexsearch cytosolsearch extracellular regionsearch endocytic vesicle lumensearch membranesearch extracellular vesicular exosomesearch cytosolic small ribosomal subunitsearch blood microparticlesearch
B (P68871) oxygen transportsearch response to hydrogen peroxidesearch small molecule metabolic processsearch renal absorptionsearch oxidation-reduction processsearch bicarbonate transportsearch positive regulation of nitric oxide biosynthetic processsearch hydrogen peroxide catabolic processsearch positive regulation of cell deathsearch blood coagulationsearch nitric oxide transportsearch transportsearch regulation of blood pressuresearch regulation of blood vessel sizesearch protein heterooligomerizationsearch platelet aggregationsearch oxygen bindingsearch heme bindingsearch iron ion bindingsearch protein bindingsearch oxygen transporter activitysearch peroxidase activitysearch haptoglobin bindingsearch metal ion bindingsearch hemoglobin bindingsearch hemoglobin complexsearch extracellular regionsearch cytosolsearch extracellular vesicular exosomesearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch blood microparticlesearch

Chain InterPro annotation
A Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch