2hbe Summary

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HIGH RESOLUTION X-RAY STRUCTURES OF MYOGLOBIN-AND HEMOGLOBIN-ALKYL ISOCYANIDE COMPLEXES

The structure was published by Johnson, K.A., in 1993 in a paper entitled "High Resolution X-Ray Structures of Myoglobin-and Hemoglobin-Alkyl Isocyanide Complexes" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 1994.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN A (N-BUTYL ISOCYANIDE) (ALPHA CHAIN) and HEMOGLOBIN A (N-BUTYL ISOCYANIDE) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN A (N-BUTYL ISOCYANIDE) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN A (N-BUTYL ISOCYANIDE) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN A (N-BUTYL ISOCYANIDE) (ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) HEMOGLOBIN A (N-BUTYL ISOCYANIDE) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P69905) heme bindingsearch oxygen bindingsearch iron ion bindingsearch protein bindingsearch metal ion bindingsearch peroxidase activitysearch oxygen transporter activitysearch haptoglobin bindingsearch hemoglobin complexsearch extracellular regionsearch cytosolsearch extracellular vesicular exosomesearch cytosolic small ribosomal subunitsearch endocytic vesicle lumensearch membranesearch haptoglobin-hemoglobin complexsearch blood microparticlesearch oxygen transportsearch bicarbonate transportsearch response to hydrogen peroxidesearch hydrogen peroxide catabolic processsearch transportsearch protein heterooligomerizationsearch small molecule metabolic processsearch oxidation-reduction processsearch positive regulation of cell deathsearch
B (P68871) oxygen bindingsearch iron ion bindingsearch oxygen transporter activitysearch protein bindingsearch heme bindingsearch metal ion bindingsearch hemoglobin bindingsearch haptoglobin bindingsearch peroxidase activitysearch blood microparticlesearch cytosolsearch haptoglobin-hemoglobin complexsearch hemoglobin complexsearch extracellular regionsearch extracellular vesicular exosomesearch endocytic vesicle lumensearch oxygen transportsearch nitric oxide transportsearch oxidation-reduction processsearch hydrogen peroxide catabolic processsearch regulation of blood pressuresearch protein heterooligomerizationsearch renal absorptionsearch platelet aggregationsearch bicarbonate transportsearch blood coagulationsearch positive regulation of cell deathsearch small molecule metabolic processsearch regulation of blood vessel sizesearch response to hydrogen peroxidesearch positive regulation of nitric oxide biosynthetic processsearch transportsearch

Chain InterPro annotation
A Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch