2hbe Summary

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HIGH RESOLUTION X-RAY STRUCTURES OF MYOGLOBIN-AND HEMOGLOBIN-ALKYL ISOCYANIDE COMPLEXES

The structure was published by Johnson, K.A., in 1993 in a paper entitled "High Resolution X-Ray Structures of Myoglobin-and Hemoglobin-Alkyl Isocyanide Complexes" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 1994.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN A (N-BUTYL ISOCYANIDE) (ALPHA CHAIN) and HEMOGLOBIN A (N-BUTYL ISOCYANIDE) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN A (N-BUTYL ISOCYANIDE) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN A (N-BUTYL ISOCYANIDE) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN A (N-BUTYL ISOCYANIDE) (ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) HEMOGLOBIN A (N-BUTYL ISOCYANIDE) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P69905) iron ion bindingsearch heme bindingsearch oxygen bindingsearch protein bindingsearch oxygen transporter activitysearch metal ion bindingsearch peroxidase activitysearch haptoglobin bindingsearch hemoglobin complexsearch extracellular regionsearch cytosolsearch cytosolic small ribosomal subunitsearch extracellular vesicular exosomesearch endocytic vesicle lumensearch membranesearch haptoglobin-hemoglobin complexsearch blood microparticlesearch oxygen transportsearch bicarbonate transportsearch response to hydrogen peroxidesearch receptor-mediated endocytosissearch hydrogen peroxide catabolic processsearch transportsearch protein heterooligomerizationsearch positive regulation of cell deathsearch small molecule metabolic processsearch oxidation-reduction processsearch
B (P68871) heme bindingsearch protein bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch hemoglobin bindingsearch peroxidase activitysearch oxygen bindingsearch metal ion bindingsearch iron ion bindingsearch blood microparticlesearch cytosolsearch hemoglobin complexsearch haptoglobin-hemoglobin complexsearch extracellular regionsearch extracellular vesicular exosomesearch endocytic vesicle lumensearch oxygen transportsearch regulation of blood vessel sizesearch nitric oxide transportsearch hydrogen peroxide catabolic processsearch renal absorptionsearch regulation of blood pressuresearch protein heterooligomerizationsearch platelet aggregationsearch transportsearch bicarbonate transportsearch response to hydrogen peroxidesearch blood coagulationsearch positive regulation of nitric oxide biosynthetic processsearch small molecule metabolic processsearch positive regulation of cell deathsearch receptor-mediated endocytosissearch oxidation-reduction processsearch

Chain InterPro annotation
A Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch