2hbe Summary

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HIGH RESOLUTION X-RAY STRUCTURES OF MYOGLOBIN-AND HEMOGLOBIN-ALKYL ISOCYANIDE COMPLEXES

The structure was published by Johnson, K.A., in 1993 in a paper entitled "High Resolution X-Ray Structures of Myoglobin-and Hemoglobin-Alkyl Isocyanide Complexes" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 1994.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN A (N-BUTYL ISOCYANIDE) (ALPHA CHAIN) and HEMOGLOBIN A (N-BUTYL ISOCYANIDE) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN A (N-BUTYL ISOCYANIDE) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN A (N-BUTYL ISOCYANIDE) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN A (N-BUTYL ISOCYANIDE) (ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) HEMOGLOBIN A (N-BUTYL ISOCYANIDE) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P69905) heme bindingsearch protein bindingsearch iron ion bindingsearch peroxidase activitysearch oxygen bindingsearch oxygen transporter activitysearch metal ion bindingsearch haptoglobin bindingsearch oxygen transportsearch bicarbonate transportsearch response to hydrogen peroxidesearch hydrogen peroxide catabolic processsearch oxidation-reduction processsearch protein heterooligomerizationsearch transportsearch small molecule metabolic processsearch positive regulation of cell deathsearch extracellular regionsearch cytosolsearch hemoglobin complexsearch extracellular vesicular exosomesearch cytosolic small ribosomal subunitsearch endocytic vesicle lumensearch membranesearch haptoglobin-hemoglobin complexsearch blood microparticlesearch
B (P68871) protein bindingsearch metal ion bindingsearch oxygen transporter activitysearch oxygen bindingsearch iron ion bindingsearch hemoglobin bindingsearch haptoglobin bindingsearch peroxidase activitysearch heme bindingsearch nitric oxide transportsearch hydrogen peroxide catabolic processsearch oxygen transportsearch renal absorptionsearch platelet aggregationsearch protein heterooligomerizationsearch transportsearch oxidation-reduction processsearch blood coagulationsearch bicarbonate transportsearch positive regulation of cell deathsearch small molecule metabolic processsearch positive regulation of nitric oxide biosynthetic processsearch response to hydrogen peroxidesearch regulation of blood pressuresearch regulation of blood vessel sizesearch blood microparticlesearch cytosolsearch haptoglobin-hemoglobin complexsearch hemoglobin complexsearch extracellular regionsearch extracellular vesicular exosomesearch endocytic vesicle lumensearch

Chain InterPro annotation
A Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch