2hbe Summary

pdbe.org/2hbe
spacer

HIGH RESOLUTION X-RAY STRUCTURES OF MYOGLOBIN-AND HEMOGLOBIN-ALKYL ISOCYANIDE COMPLEXES

The structure was published by Johnson, K.A., in 1993 in a paper entitled "High Resolution X-Ray Structures of Myoglobin-and Hemoglobin-Alkyl Isocyanide Complexes" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 1994.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN A (N-BUTYL ISOCYANIDE) (ALPHA CHAIN) and HEMOGLOBIN A (N-BUTYL ISOCYANIDE) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN A (N-BUTYL ISOCYANIDE) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN A (N-BUTYL ISOCYANIDE) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN A (N-BUTYL ISOCYANIDE) (ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) HEMOGLOBIN A (N-BUTYL ISOCYANIDE) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P69905) heme bindingsearch protein bindingsearch oxygen transporter activitysearch peroxidase activitysearch metal ion bindingsearch haptoglobin bindingsearch iron ion bindingsearch oxygen bindingsearch cytosolsearch extracellular vesicular exosomesearch extracellular regionsearch hemoglobin complexsearch endocytic vesicle lumensearch cytosolic small ribosomal subunitsearch haptoglobin-hemoglobin complexsearch membranesearch blood microparticlesearch response to hydrogen peroxidesearch bicarbonate transportsearch transportsearch protein heterooligomerizationsearch oxygen transportsearch hydrogen peroxide catabolic processsearch small molecule metabolic processsearch oxidation-reduction processsearch positive regulation of cell deathsearch
B (P68871) heme bindingsearch oxygen transporter activitysearch protein bindingsearch hemoglobin bindingsearch haptoglobin bindingsearch oxygen bindingsearch peroxidase activitysearch metal ion bindingsearch iron ion bindingsearch haptoglobin-hemoglobin complexsearch cytosolsearch hemoglobin complexsearch extracellular vesicular exosomesearch extracellular regionsearch endocytic vesicle lumensearch blood microparticlesearch protein heterooligomerizationsearch platelet aggregationsearch hydrogen peroxide catabolic processsearch oxygen transportsearch renal absorptionsearch regulation of blood pressuresearch regulation of blood vessel sizesearch positive regulation of cell deathsearch small molecule metabolic processsearch bicarbonate transportsearch oxidation-reduction processsearch blood coagulationsearch response to hydrogen peroxidesearch transportsearch positive regulation of nitric oxide biosynthetic processsearch nitric oxide transportsearch

Chain InterPro annotation
A Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch