2hbd Summary

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HIGH RESOLUTION X-RAY STRUCTURES OF MYOGLOBIN-AND HEMOGLOBIN-ALKYL ISOCYANIDE COMPLEXES

The structure was published by Johnson, K.A., in 1993 in a paper entitled "High Resolution X-Ray Structures of Myoglobin-and Hemoglobin-Alkyl Isocyanide Complexes" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 1994.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN A (METHYL ISOCYANIDE) (ALPHA CHAIN) and HEMOGLOBIN A (METHYL ISOCYANIDE) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN A (METHYL ISOCYANIDE) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN A (METHYL ISOCYANIDE) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN A (METHYL ISOCYANIDE) (ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) HEMOGLOBIN A (METHYL ISOCYANIDE) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P69905) oxygen bindingsearch heme bindingsearch iron ion bindingsearch haptoglobin bindingsearch protein bindingsearch oxygen transporter activitysearch metal ion bindingsearch peroxidase activitysearch oxygen transportsearch positive regulation of cell deathsearch hydrogen peroxide catabolic processsearch bicarbonate transportsearch response to hydrogen peroxidesearch transportsearch oxidation-reduction processsearch small molecule metabolic processsearch protein heterooligomerizationsearch receptor-mediated endocytosissearch hemoglobin complexsearch extracellular regionsearch extracellular exosomesearch cytosolsearch blood microparticlesearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch membranesearch cytosolic small ribosomal subunitsearch
B (P68871) heme bindingsearch iron ion bindingsearch oxygen bindingsearch peroxidase activitysearch protein bindingsearch hemoglobin bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch metal ion bindingsearch oxygen transportsearch bicarbonate transportsearch positive regulation of nitric oxide biosynthetic processsearch positive regulation of cell deathsearch nitric oxide transportsearch regulation of blood pressuresearch receptor-mediated endocytosissearch renal absorptionsearch small molecule metabolic processsearch platelet aggregationsearch oxidation-reduction processsearch transportsearch hydrogen peroxide catabolic processsearch protein heterooligomerizationsearch blood coagulationsearch response to hydrogen peroxidesearch regulation of blood vessel sizesearch hemoglobin complexsearch cytosolsearch extracellular exosomesearch extracellular regionsearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch blood microparticlesearch

Chain InterPro annotation
A Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch