2hbd Summary

pdbe.org/2hbd
spacer

HIGH RESOLUTION X-RAY STRUCTURES OF MYOGLOBIN-AND HEMOGLOBIN-ALKYL ISOCYANIDE COMPLEXES

The structure was published by Johnson, K.A., in 1993 in a paper entitled "High Resolution X-Ray Structures of Myoglobin-and Hemoglobin-Alkyl Isocyanide Complexes" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 1994.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN A (METHYL ISOCYANIDE) (ALPHA CHAIN) and HEMOGLOBIN A (METHYL ISOCYANIDE) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN A (METHYL ISOCYANIDE) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN A (METHYL ISOCYANIDE) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN A (METHYL ISOCYANIDE) (ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) HEMOGLOBIN A (METHYL ISOCYANIDE) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P69905) heme bindingsearch iron ion bindingsearch oxygen bindingsearch protein bindingsearch haptoglobin bindingsearch oxygen transporter activitysearch peroxidase activitysearch metal ion bindingsearch positive regulation of cell deathsearch bicarbonate transportsearch hydrogen peroxide catabolic processsearch oxygen transportsearch oxidation-reduction processsearch transportsearch protein heterooligomerizationsearch small molecule metabolic processsearch response to hydrogen peroxidesearch hemoglobin complexsearch extracellular regionsearch blood microparticlesearch endocytic vesicle lumensearch cytosolsearch extracellular vesicular exosomesearch membranesearch haptoglobin-hemoglobin complexsearch cytosolic small ribosomal subunitsearch
B (P68871) heme bindingsearch oxygen bindingsearch iron ion bindingsearch peroxidase activitysearch metal ion bindingsearch protein bindingsearch hemoglobin bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch oxygen transportsearch bicarbonate transportsearch positive regulation of cell deathsearch regulation of blood pressuresearch regulation of blood vessel sizesearch positive regulation of nitric oxide biosynthetic processsearch renal absorptionsearch oxidation-reduction processsearch small molecule metabolic processsearch nitric oxide transportsearch blood coagulationsearch hydrogen peroxide catabolic processsearch protein heterooligomerizationsearch response to hydrogen peroxidesearch transportsearch hemoglobin complexsearch cytosolsearch extracellular vesicular exosomesearch extracellular regionsearch haptoglobin-hemoglobin complexsearch blood microparticlesearch endocytic vesicle lumensearch

Chain InterPro annotation
A Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch