2hbc Summary

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HIGH RESOLUTION X-RAY STRUCTURES OF MYOGLOBIN-AND HEMOGLOBIN-ALKYL ISOCYANIDE COMPLEXES

The structure was published by Johnson, K.A., in 1993 in a paper entitled "High Resolution X-Ray Structures of Myoglobin-and Hemoglobin-Alkyl Isocyanide Complexes" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 1994.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN A (ETHYL ISOCYANIDE) (ALPHA CHAIN) and HEMOGLOBIN A (ETHYL ISOCYANIDE) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN A (ETHYL ISOCYANIDE) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN A (ETHYL ISOCYANIDE) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN A (ETHYL ISOCYANIDE) (ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) HEMOGLOBIN A (ETHYL ISOCYANIDE) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P69905) heme bindingsearch oxygen bindingsearch protein bindingsearch peroxidase activitysearch oxygen transporter activitysearch iron ion bindingsearch haptoglobin bindingsearch metal ion bindingsearch oxygen transportsearch oxidation-reduction processsearch response to hydrogen peroxidesearch hydrogen peroxide catabolic processsearch protein heterooligomerizationsearch bicarbonate transportsearch positive regulation of cell deathsearch small molecule metabolic processsearch receptor-mediated endocytosissearch transportsearch extracellular regionsearch hemoglobin complexsearch haptoglobin-hemoglobin complexsearch extracellular vesicular exosomesearch blood microparticlesearch membranesearch cytosolic small ribosomal subunitsearch cytosolsearch endocytic vesicle lumensearch
B (P68871) heme bindingsearch protein bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch metal ion bindingsearch hemoglobin bindingsearch peroxidase activitysearch oxygen bindingsearch iron ion bindingsearch oxygen transportsearch renal absorptionsearch hydrogen peroxide catabolic processsearch bicarbonate transportsearch protein heterooligomerizationsearch regulation of blood vessel sizesearch nitric oxide transportsearch oxidation-reduction processsearch positive regulation of cell deathsearch blood coagulationsearch receptor-mediated endocytosissearch response to hydrogen peroxidesearch positive regulation of nitric oxide biosynthetic processsearch platelet aggregationsearch small molecule metabolic processsearch transportsearch regulation of blood pressuresearch extracellular regionsearch cytosolsearch hemoglobin complexsearch endocytic vesicle lumensearch blood microparticlesearch extracellular vesicular exosomesearch haptoglobin-hemoglobin complexsearch

Chain InterPro annotation
A Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch