2hbc Summary

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HIGH RESOLUTION X-RAY STRUCTURES OF MYOGLOBIN-AND HEMOGLOBIN-ALKYL ISOCYANIDE COMPLEXES

The structure was published by Johnson, K.A., in 1993 in a paper entitled "High Resolution X-Ray Structures of Myoglobin-and Hemoglobin-Alkyl Isocyanide Complexes" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 1994.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN A (ETHYL ISOCYANIDE) (ALPHA CHAIN) and HEMOGLOBIN A (ETHYL ISOCYANIDE) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN A (ETHYL ISOCYANIDE) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN A (ETHYL ISOCYANIDE) (BETA CHAIN) P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN A (ETHYL ISOCYANIDE) (ALPHA CHAIN) Homo sapiens
P68871 (2 - 147) HEMOGLOBIN A (ETHYL ISOCYANIDE) (BETA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P69905) hemoglobin complexsearch extracellular regionsearch blood microparticlesearch haptoglobin-hemoglobin complexsearch extracellular vesicular exosomesearch membranesearch cytosolsearch endocytic vesicle lumensearch cytosolic small ribosomal subunitsearch transportsearch small molecule metabolic processsearch bicarbonate transportsearch positive regulation of cell deathsearch response to hydrogen peroxidesearch hydrogen peroxide catabolic processsearch protein heterooligomerizationsearch oxidation-reduction processsearch oxygen transportsearch peroxidase activitysearch oxygen bindingsearch protein bindingsearch metal ion bindingsearch haptoglobin bindingsearch iron ion bindingsearch oxygen transporter activitysearch heme bindingsearch
B (P68871) cytosolsearch hemoglobin complexsearch extracellular regionsearch endocytic vesicle lumensearch extracellular vesicular exosomesearch haptoglobin-hemoglobin complexsearch blood microparticlesearch renal absorptionsearch hydrogen peroxide catabolic processsearch oxygen transportsearch regulation of blood pressuresearch oxidation-reduction processsearch bicarbonate transportsearch protein heterooligomerizationsearch nitric oxide transportsearch regulation of blood vessel sizesearch transportsearch response to hydrogen peroxidesearch positive regulation of nitric oxide biosynthetic processsearch small molecule metabolic processsearch positive regulation of cell deathsearch platelet aggregationsearch blood coagulationsearch protein bindingsearch iron ion bindingsearch oxygen transporter activitysearch heme bindingsearch haptoglobin bindingsearch hemoglobin bindingsearch peroxidase activitysearch metal ion bindingsearch oxygen bindingsearch

Chain InterPro annotation
A Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch