2hbc Summary

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HIGH RESOLUTION X-RAY STRUCTURES OF MYOGLOBIN-AND HEMOGLOBIN-ALKYL ISOCYANIDE COMPLEXES

The structure was published by Johnson, K.A., in 1993 in a paper entitled "High Resolution X-Ray Structures of Myoglobin-and Hemoglobin-Alkyl Isocyanide Complexes" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 1994.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely HEMOGLOBIN A (ETHYL ISOCYANIDE) (ALPHA CHAIN) and HEMOGLOBIN A (ETHYL ISOCYANIDE) (BETA CHAIN).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HEMOGLOBIN A (ETHYL ISOCYANIDE) (ALPHA CHAIN) P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B HEMOGLOBIN A (ETHYL ISOCYANIDE) (BETA CHAIN) Not available
Homo sapienssearch Not available 146 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P69905 (2 - 142) HEMOGLOBIN A (ETHYL ISOCYANIDE) (ALPHA CHAIN) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B (P68871)

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P69905) oxygen transportsearch response to hydrogen peroxidesearch hydrogen peroxide catabolic processsearch positive regulation of cell deathsearch protein heterooligomerizationsearch bicarbonate transportsearch transportsearch oxidation-reduction processsearch small molecule metabolic processsearch heme bindingsearch oxygen bindingsearch peroxidase activitysearch protein bindingsearch oxygen transporter activitysearch metal ion bindingsearch iron ion bindingsearch haptoglobin bindingsearch membranesearch extracellular regionsearch blood microparticlesearch hemoglobin complexsearch haptoglobin-hemoglobin complexsearch extracellular vesicular exosomesearch cytosolsearch cytosolic small ribosomal subunitsearch endocytic vesicle lumensearch
B () oxygen transportsearch hydrogen peroxide catabolic processsearch oxidation-reduction processsearch bicarbonate transportsearch renal absorptionsearch response to hydrogen peroxidesearch nitric oxide transportsearch protein heterooligomerizationsearch regulation of blood vessel sizesearch positive regulation of nitric oxide biosynthetic processsearch positive regulation of cell deathsearch small molecule metabolic processsearch transportsearch platelet aggregationsearch blood coagulationsearch regulation of blood pressuresearch heme bindingsearch protein bindingsearch oxygen transporter activitysearch hemoglobin bindingsearch peroxidase activitysearch haptoglobin bindingsearch oxygen bindingsearch iron ion bindingsearch metal ion bindingsearch extracellular regionsearch cytosolsearch endocytic vesicle lumensearch hemoglobin complexsearch extracellular vesicular exosomesearch haptoglobin-hemoglobin complexsearch blood microparticlesearch

Chain InterPro annotation
A Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch