2hb8 Summary

pdbe.org/2hb8
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Crystal structure of VDR LBD in complex with 2alpha-methyl calcitriol

The structure was published by Hourai, S., Fujishima, T., Kittaka, A., et al., Takayama, H., Rochel, N., and Moras, D., in 2006 in a paper entitled "Probing a Water Channel near the A-Ring of Receptor-Bound 1alpha,25-Dihydroxyvitamin D3 with Selected 2alpha-Substituted Analogues" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Vitamin D3 receptor. This molecule has the UniProt identifier P11473 (VDR_HUMAN)search. The sample contained 263 residues which is < 90% of the natural sequence. Out of 263 residues 254 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Vitamin D3 receptor P11473 (118-427) (VDR_HUMAN)search Homo sapienssearch < 90% 263 96%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P11473 (118 - 427) Vitamin D3 receptor Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P11473) DNA bindingsearch sequence-specific DNA binding transcription factor activitysearch steroid hormone receptor activitysearch thyroid hormone receptor activitysearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch nucleussearch

Chain InterPro annotation
A Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Thyroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch