2han Summary

pdbe.org/2han
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Structural basis of heterodimeric ecdysteroid receptor interaction with natural response element hsp27 gene promoter

The structure was published by Jakob, M., Kolodziejczyk, R., Orlowski, M., et al., Kochman, M., Jaskolski, M., and Ozyhar, A., in 2007 in a paper entitled "Novel DNA-binding element within the C-terminal extension of the nuclear receptor DNA-binding domain." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.95 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This entry contains 12 copies of 4 unique biopolymers (complete list).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Protein ultraspiracle P20153 (94-179) (USP_DROME)search Drosophila melanogastersearch < 90% 93 83%
B Ecdysone receptor P34021 (256-365) (ECR_DROME)search Drosophila melanogastersearch < 90% 119 73%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P20153 (94 - 179) Protein ultraspiracle Drosophila melanogaster
P34021 (256 - 365) Ecdysone receptor Drosophila melanogaster

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Nuclear receptorsearch Erythroid Transcription Factor GATA-1, subunit Asearch Zinc finger, C4 type (two domains)search
B Nuclear receptorsearch Erythroid Transcription Factor GATA-1, subunit Asearch Zinc finger, C4 type (two domains)search

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P20153) regulation of transcription, DNA-templatedsearch zinc ion bindingsearch sequence-specific DNA binding transcription factor activitysearch sequence-specific DNA bindingsearch nucleussearch
B (P34021) regulation of transcription, DNA-templatedsearch zinc ion bindingsearch sequence-specific DNA binding transcription factor activitysearch sequence-specific DNA bindingsearch steroid hormone receptor activitysearch nucleussearch

Chain InterPro annotation
A Zinc finger, nuclear hormone receptor-typesearch Zinc finger, NHR/GATA-typesearch
B Zinc finger, nuclear hormone receptor-typesearch Nuclear hormone receptor, ligand-bindingsearch Zinc finger, NHR/GATA-typesearch