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EBI PDBe PDBeView

PDBe Entry: 2ha6 view

Crystal structure of mutant S203A of mouse acetylcholinesterase complexed with succinylcholine
Summary
Header Hydrolasesearch
Method X-RAY DIFFRACTION
Experiment Resolution: 2.25 Å, R-factor: 17.765%, Free R-factor: 19.832%, Spacegroup: P 21 21 21
Released 18/07/2006, deposition: 12/06/2006, last revision: 24/02/2009
Authors Bourne, Y.search; Radic, Z.search; Sulzenbacher, G.search; Kim, E.search; Taylor, P.search; Marchot, P.search
Primary citation Substrate and product trafficking through the active center gorge of acetylcholinesterase analyzed by crystallography and equilibrium binding
J.BIOL.CHEM.search vol:281, pag:29256-29267 (2006) [PubMed ID 16837465 ]search
Keywords HYDROLASE FOLDsearch, SERINE ESTERASEsearch, ACETYLCHOLINESTERASEsearch, MUTANTsearch, HOMODIMERsearch, GLYCOSYLATED PROTEINsearch
EC 3.1.1.7 ExPASy BRENDA search (A B)
Organism Mus musculus(house mouse) 10090search(A B)
UniProt Acetylcholinesterase precursor (EC 3.1.1.7) (AChE) P21836search (A B)
Solvent A, B
Related entries 1j06, 2h9y, 2ha0, 2ha2, 2ha3, 2ha4, 2ha5, 2ha7
Polymers
Id Name Type UniProt Residues Observed
A, B Acetylcholinesterase Protein P21836 (ACES_MOUSE)search
 543 98%
Heterogens
Id Name Ligands
A, B 2,2'-[(1,4-DIOXOBUTANE-1,4-DIYL)BIS(OXY)]BIS(N,N,N-TRIMETHYLETHANAMINIUM) SCK search
A HEXAETHYLENE GLYCOL P6G search
A ACETIC ACID ACY search
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