2h9v Summary


Structural basis for induced-fit binding of Rho-kinase to the inhibitor Y27632

The structure was published by Yamaguchi, H., Miwa, Y., Kasa, M., et al., Amano, M., Kaibuchi, K., and Hakoshima, T., in 2006 in a paper entitled "Structural basis for induced-fit binding of Rho-kinase to the inhibitor Y-27632" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.1 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Rho-associated protein kinase 2. This molecule has the UniProt identifier Q28021 (ROCK2_BOVIN)search. The sample contained 402 residues which is < 90% of the natural sequence. Out of 402 residues 383 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Rho-associated protein kinase 2 Q28021 (18-417) (ROCK2_BOVIN)search Bos taurussearch < 90% 402 95%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q28021 (18 - 417) Rho-associated protein kinase 2 Bos taurus

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (Q28021) protein serine/threonine kinase activitysearch protein kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch AGC-kinase, C-terminalsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch