2h8r Summary


Hepatocyte Nuclear Factor 1b bound to DNA: MODY5 Gene Product

The structure was published by Lu, P., Rha, G.B., and Chi, Y.I., in 2007 in a paper entitled "Structural basis of disease-causing mutations in hepatocyte nuclear factor 1beta." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.2 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely 5'-D(*CP*TP*TP*GP*GP*TP*TP*AP*AP*TP*AP*AP*TP*TP*CP*AP*CP*CP*AP*G)-3', 5'-D(*GP*CP*TP*GP*GP*TP*GP*AP*AP*TP*TP*AP*TP*TP*AP*AP*CP*CP*AP*A)-3', and Hepatocyte nuclear factor 1-beta.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hepatocyte nuclear factor 1-beta P35680 (91-310) (HNF1B_HUMAN)search Homo sapienssearch < 90% 221 79%
B Hepatocyte nuclear factor 1-beta P35680 (91-310) (HNF1B_HUMAN)search Homo sapienssearch < 90% 221 79%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P35680 (91 - 310) Hepatocyte nuclear factor 1-beta Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B lambda repressor-like DNA-binding domainssearch, Homeodomain-likesearch Homeobox domainsearch, Hepatocyte nuclear factor 1 (HNF-1), N terminussearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P35680) DNA bindingsearch positive regulation of transcription, DNA-templatedsearch nucleussearch

Chain InterPro annotation
A, B Homeobox domainsearch Hepatocyte nuclear factor 1, N-terminalsearch Homeodomain-likesearch Lambda repressor-like, DNA-binding domainsearch