2h8h Summary

pdbe.org/2h8h
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Src kinase in complex with a quinazoline inhibitor

The structure was published by Hennequin, L.F., Allen, J., Breed, J., et al., Ple, P.A., Warin, N., and Costello, G., in 2006 in a paper entitled "N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Proto-oncogene tyrosine-protein kinase Src. This molecule has the UniProt identifier P12931 (SRC_HUMAN)search. The sample contained 535 residues which is 100% of the natural sequence. Out of 535 residues 444 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Proto-oncogene tyrosine-protein kinase Src P12931 (2-536) (SRC_HUMAN)search Homo sapienssearch 100% 535 83%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P12931 (2 - 536) Proto-oncogene tyrosine-protein kinase Src Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P12931) SH3-domainsearch, SH2 domainsearch, Protein kinases, catalytic subunitsearch SH3 Domainssearch, SHC Adaptor Proteinsearch, Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00017: SH2 domainsearch, PF00018: SH3 domainsearch, PF07714: Protein tyrosine kinasesearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P12931) cytosolsearch plasma membranesearch mitochondrial inner membranesearch cytoskeletonsearch cytoplasmsearch nucleussearch mitochondrionsearch membranesearch late endosomesearch caveolasearch lysosomesearch signal transductionsearch innate immune responsesearch branching involved in mammary gland duct morphogenesissearch cell cyclesearch protein autophosphorylationsearch regulation of intracellular estrogen receptor signaling pathwaysearch positive regulation of integrin activationsearch peptidyl-tyrosine phosphorylationsearch protein phosphorylationsearch negative regulation of cysteine-type endopeptidase activity involved in apoptotic processsearch signal complex assemblysearch T cell costimulationsearch negative regulation of focal adhesion assemblysearch regulation of protein bindingsearch intracellular protein kinase cascadesearch oogenesissearch cell adhesionsearch platelet activationsearch cell migrationsearch negative regulation of intrinsic apoptotic signaling pathwaysearch blood coagulationsearch cellular response to progesterone stimulussearch negative regulation of extrinsic apoptotic signaling pathwaysearch Ras protein signal transductionsearch progesterone receptor signaling pathwaysearch negative regulation of anoikissearch modulation by virus of host morphology or physiologysearch Fc-gamma receptor signaling pathway involved in phagocytosissearch positive regulation of protein kinase B signaling cascadesearch negative regulation of protein homooligomerizationsearch uterus developmentsearch epidermal growth factor receptor signaling pathwaysearch neurotrophin TRK receptor signaling pathwaysearch regulation of vascular permeabilitysearch axon guidancesearch regulation of bone resorptionsearch fibroblast growth factor receptor signaling pathwaysearch response to interleukin-1search positive regulation of canonical Wnt receptor signaling pathwaysearch positive regulation of ERK1 and ERK2 cascadesearch bone resorptionsearch positive regulation of podosome assemblysearch forebrain developmentsearch leukocyte migrationsearch phosphorylationsearch SH2 domain bindingsearch protein bindingsearch identical protein bindingsearch ion channel bindingsearch protein kinase activitysearch protein tyrosine kinase activitysearch ATP bindingsearch SH3/SH2 adaptor activitysearch ephrin receptor bindingsearch transferase activity, transferring phosphorus-containing groupssearch non-membrane spanning protein tyrosine kinase activitysearch protein domain specific bindingsearch transferase activitysearch phosphoprotein bindingsearch nucleotide bindingsearch receptor bindingsearch kinase activitysearch integrin bindingsearch heme bindingsearch

Chain InterPro annotation
A Protein kinase domainsearch SH2 domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Src homology-3 domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch