2h79 Summary


Crystal Structure of human TR alpha bound T3 in orthorhombic space group

The structure was published by Nascimento, A.S., Dias, S.M.G., Nunes, F.M., et al., Baxter, J.D., Webb, P., and Polikarpov, I., in 2006 in a paper entitled "Structural rearrangements in the thyroid hormone receptor hinge domain and their putative role in the receptor function." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.87 Å and deposited in 2006.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of THRA protein. This molecule has the UniProt identifier P10827 (THA_HUMAN)search. The sample contained 269 residues which is < 90% of the natural sequence. Out of 269 residues 267 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A THRA protein P10827 (148-370) (THA_HUMAN)search Homo sapienssearch < 90% 269 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P10827 (148 - 370) THRA protein Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P10827) thyroid hormone receptor activitysearch steroid hormone receptor activitysearch DNA bindingsearch sequence-specific DNA binding transcription factor activitysearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch nucleussearch

Chain InterPro annotation
A Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Thyroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch