› 2h63

X-ray diffraction
2.7Å resolution

Crystal Structure of Human Biliverdin Reductase A

Released:
DOI: 10.2210/pdb2h63/pdb
PDB entry 2h63 coloured by chain, front view.
PDB entry 2h63 coloured by chain, side view.
PDB entry 2h63 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Kavanagh K, Elkins J, Ugochukwu E, Guo K, Pilka E, Lukacik P, Smee C, Papagrigoriou E, Bunkoczi G, Sundstrom M, Arrowsmith C, Weigelt J, Edwards A, von Delft F, Oppermann U, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
Bilirubin + NAD(P)(+) = biliverdin + NAD(P)H
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156689 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Biliverdin reductase A Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 292 amino acids
Theoretical weight: 33.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P53004 (Residues: 7-296; Coverage: 98%)
Gene names: BLVR, BLVRA, BVR
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand NAP 4 x NAP
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 90.787Å b: 92.747Å c: 147.755Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.239 0.237 0.287
Expression system: Escherichia coli

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