2h61 Summary

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X-ray structure of human Ca2+-loaded S100B

The structure was published by Ostendorp, T., Leclerc, E., Galichet, A., et al., Heizmann, C.W., Kroneck, P.M., and Fritz, G., in 2007 in a paper entitled "Structural and functional insights into RAGE activation by multimeric S100B." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Protein S100-B.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterooctamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Protein S100-B P04271 (1-92) (S100B_HUMAN)search Homo sapienssearch 99% 92 100%
B Protein S100-B P04271 (1-92) (S100B_HUMAN)search Homo sapienssearch 99% 92 100%
E Protein S100-B P04271 (1-92) (S100B_HUMAN)search Homo sapienssearch 99% 92 100%
F Protein S100-B P04271 (1-92) (S100B_HUMAN)search Homo sapienssearch 99% 92 100%
H Protein S100-B P04271 (1-92) (S100B_HUMAN)search Homo sapienssearch 99% 92 100%
C Protein S100-B P04271 (1-92) (S100B_HUMAN)search Homo sapienssearch 99% 92 98%
D Protein S100-B P04271 (1-92) (S100B_HUMAN)search Homo sapienssearch 99% 92 98%
G Protein S100-B P04271 (1-92) (S100B_HUMAN)search Homo sapienssearch 99% 92 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P04271 (1 - 92) Protein S100-B Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, E, F, H (P04271) S100 proteinssearch EF-handsearch PF01023: S-100/ICaBP type calcium binding domainsearch
C, D, G (P04271) S100 proteinssearch EF-handsearch PF01023: S-100/ICaBP type calcium binding domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B, E, F, H (P04271) calcium ion bindingsearch zinc ion bindingsearch protein bindingsearch metal ion bindingsearch receptor bindingsearch protein homodimerization activitysearch RAGE receptor bindingsearch S100 protein bindingsearch identical protein bindingsearch tau protein bindingsearch calcium-dependent protein bindingsearch cellular response to hypoxiasearch regulation of cell shapesearch long-term synaptic potentiationsearch central nervous system developmentsearch astrocyte differentiationsearch positive regulation of I-kappaB kinase/NF-kappaB signalingsearch cell proliferationsearch response to glucocorticoidsearch positive regulation of apoptotic processsearch learning or memorysearch regulation of neuronal synaptic plasticitysearch response to methylmercurysearch axonogenesissearch negative regulation of skeletal muscle cell differentiationsearch memorysearch positive regulation of synaptic transmissionsearch innate immune responsesearch positive regulation of cell proliferationsearch extracellular regionsearch nucleussearch intracellular membrane-bounded organellesearch extracellular spacesearch cytoplasmsearch neuronal cell bodysearch rufflesearch perinuclear region of cytoplasmsearch
C, D, G (P04271) calcium ion bindingsearch protein bindingsearch receptor bindingsearch RAGE receptor bindingsearch S100 protein bindingsearch zinc ion bindingsearch identical protein bindingsearch tau protein bindingsearch calcium-dependent protein bindingsearch protein homodimerization activitysearch metal ion bindingsearch long-term synaptic potentiationsearch innate immune responsesearch response to glucocorticoidsearch memorysearch positive regulation of synaptic transmissionsearch cell proliferationsearch regulation of cell shapesearch axonogenesissearch regulation of neuronal synaptic plasticitysearch astrocyte differentiationsearch central nervous system developmentsearch cellular response to hypoxiasearch positive regulation of apoptotic processsearch learning or memorysearch positive regulation of cell proliferationsearch response to methylmercurysearch positive regulation of I-kappaB kinase/NF-kappaB signalingsearch negative regulation of skeletal muscle cell differentiationsearch neuronal cell bodysearch nucleussearch cytoplasmsearch rufflesearch extracellular regionsearch intracellular membrane-bounded organellesearch perinuclear region of cytoplasmsearch extracellular spacesearch

Chain InterPro annotation
A, B, E, F, H S100/Calbindin-D9k, conserved sitesearch EF-hand domainsearch EF-hand domain pairsearch S100/CaBP-9k-type, calcium binding, subdomainsearch EF-Hand 1, calcium-binding sitesearch Protein S100-Bsearch
C, D, G S100/Calbindin-D9k, conserved sitesearch EF-hand domainsearch EF-hand domain pairsearch S100/CaBP-9k-type, calcium binding, subdomainsearch EF-Hand 1, calcium-binding sitesearch Protein S100-Bsearch