Crystal structure of PTP1B with monocyclic thiophene inhibitor
The structure was published by Wan, Z.K., Lee, J., Xu, W., et al., Joseph-McCarthy, D., Follows, B.C., and Zhang, Y.L., in 2006 in a paper entitled "Monocyclic thiophenes as protein tyrosine phosphatase 1B inhibitors: Capturing interactions with Asp48." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2006.
The experimental data on which the structure is based was not deposited.
The PDB entry contains the structure of Tyrosine-protein phosphatase non-receptor type 1. This molecule has the UniProt identifier P18031 (PTN1_HUMAN). The sample contained 299 residues which is < 90% of the natural sequence. Out of 299 residues 297 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: