2h46 Summary

pdbe.org/2h46
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Native domain-swapped dimer crystal structure of the Grb2 SH2 domain

The structure was published by Benfield, A.P., Whiddon, B.B., Clements, J.H., and Martin, S.F., in 2007 in a paper entitled "Structural and energetic aspects of Grb2-SH2 domain-swapping." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Growth Receptor Binding Protein 2. This molecule has the UniProt identifier P62993 (GRB2_HUMAN)search. The sample contained 116 residues which is < 90% of the natural sequence. Out of 116 residues 98 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
E Growth Receptor Binding Protein 2 P62993 (53-162) (GRB2_HUMAN)search Homo sapienssearch 100% 116 84%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P62993 (53 - 162) Growth Receptor Binding Protein 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
E (P62993) SH2 domainsearch SHC Adaptor Proteinsearch PF00017: SH2 domainsearch, PF00018: SH3 domainsearch
Chain InterPro annotation
E SH2 domainsearch