2h35 Summary

pdbe.org/2h35
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Solution structure of Human normal adult hemoglobin

The structure was published by Xu, Y., Zheng, Y., Fan, J.S., and Yang, D., in 2006 in a paper entitled "A new strategy for structure determination of large proteins in solution without deuteration" (abstract).

The structure was determined using NMR spectroscopy and deposited in 2006.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha subunit and Hemoglobin beta subunit.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha subunit P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha subunit P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta subunit P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta subunit P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha subunit Homo sapiens
P68871 (2 - 147) Hemoglobin beta subunit Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, C (P69905) oxygen bindingsearch iron ion bindingsearch heme bindingsearch oxygen transporter activitysearch protein bindingsearch metal ion bindingsearch haptoglobin bindingsearch peroxidase activitysearch extracellular vesicular exosomesearch hemoglobin complexsearch cytosolsearch extracellular regionsearch endocytic vesicle lumensearch membranesearch blood microparticlesearch cytosolic small ribosomal subunitsearch haptoglobin-hemoglobin complexsearch bicarbonate transportsearch protein heterooligomerizationsearch positive regulation of cell deathsearch transportsearch response to hydrogen peroxidesearch oxygen transportsearch hydrogen peroxide catabolic processsearch small molecule metabolic processsearch oxidation-reduction processsearch
B, D (P68871) heme bindingsearch metal ion bindingsearch oxygen transporter activitysearch protein bindingsearch oxygen bindingsearch haptoglobin bindingsearch peroxidase activitysearch iron ion bindingsearch hemoglobin bindingsearch haptoglobin-hemoglobin complexsearch extracellular regionsearch blood microparticlesearch hemoglobin complexsearch extracellular vesicular exosomesearch cytosolsearch endocytic vesicle lumensearch renal absorptionsearch oxygen transportsearch regulation of blood vessel sizesearch nitric oxide transportsearch positive regulation of cell deathsearch blood coagulationsearch small molecule metabolic processsearch response to hydrogen peroxidesearch regulation of blood pressuresearch oxidation-reduction processsearch positive regulation of nitric oxide biosynthetic processsearch bicarbonate transportsearch protein heterooligomerizationsearch transportsearch hydrogen peroxide catabolic processsearch platelet aggregationsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch