2h35 Summary

pdbe.org/2h35
spacer

Solution structure of Human normal adult hemoglobin

The structure was published by Xu, Y., Zheng, Y., Fan, J.S., and Yang, D., in 2006 in a paper entitled "A new strategy for structure determination of large proteins in solution without deuteration" (abstract).

The structure was determined using NMR spectroscopy and deposited in 2006.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha subunit and Hemoglobin beta subunit.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha subunit P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha subunit P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta subunit P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta subunit P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha subunit Homo sapiens
P68871 (2 - 147) Hemoglobin beta subunit Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P69905) oxygen bindingsearch iron ion bindingsearch protein bindingsearch peroxidase activitysearch oxygen transporter activitysearch heme bindingsearch metal ion bindingsearch haptoglobin bindingsearch oxygen transportsearch bicarbonate transportsearch hydrogen peroxide catabolic processsearch oxidation-reduction processsearch small molecule metabolic processsearch receptor-mediated endocytosissearch protein heterooligomerizationsearch transportsearch positive regulation of cell deathsearch response to hydrogen peroxidesearch cytosolsearch extracellular regionsearch extracellular vesicular exosomesearch cytosolic small ribosomal subunitsearch blood microparticlesearch haptoglobin-hemoglobin complexsearch hemoglobin complexsearch membranesearch endocytic vesicle lumensearch
B, D (P68871) heme bindingsearch haptoglobin bindingsearch protein bindingsearch oxygen transporter activitysearch oxygen bindingsearch metal ion bindingsearch peroxidase activitysearch hemoglobin bindingsearch iron ion bindingsearch oxygen transportsearch bicarbonate transportsearch regulation of blood vessel sizesearch positive regulation of nitric oxide biosynthetic processsearch protein heterooligomerizationsearch blood coagulationsearch oxidation-reduction processsearch hydrogen peroxide catabolic processsearch platelet aggregationsearch small molecule metabolic processsearch regulation of blood pressuresearch transportsearch renal absorptionsearch nitric oxide transportsearch positive regulation of cell deathsearch response to hydrogen peroxidesearch receptor-mediated endocytosissearch extracellular vesicular exosomesearch cytosolsearch extracellular regionsearch hemoglobin complexsearch blood microparticlesearch haptoglobin-hemoglobin complexsearch endocytic vesicle lumensearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch