2h35 Summary

pdbe.org/2h35
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Solution structure of Human normal adult hemoglobin

The structure was published by Xu, Y., Zheng, Y., Fan, J.S., and Yang, D., in 2006 in a paper entitled "A new strategy for structure determination of large proteins in solution without deuteration" (abstract).

The structure was determined using NMR spectroscopy and deposited in 2006.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha subunit and Hemoglobin beta subunit.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha subunit P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha subunit P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta subunit P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta subunit P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha subunit Homo sapiens
P68871 (2 - 147) Hemoglobin beta subunit Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, C (P69905) hemoglobin complexsearch extracellular regionsearch cytosolsearch extracellular exosomesearch endocytic vesicle lumensearch membranesearch blood microparticlesearch cytosolic small ribosomal subunitsearch haptoglobin-hemoglobin complexsearch oxygen transportsearch transportsearch bicarbonate transportsearch positive regulation of cell deathsearch oxidation-reduction processsearch protein heterooligomerizationsearch receptor-mediated endocytosissearch response to hydrogen peroxidesearch hydrogen peroxide catabolic processsearch small molecule metabolic processsearch heme bindingsearch oxygen bindingsearch iron ion bindingsearch protein bindingsearch metal ion bindingsearch haptoglobin bindingsearch peroxidase activitysearch oxygen transporter activitysearch
B, D (P68871) hemoglobin complexsearch extracellular regionsearch haptoglobin-hemoglobin complexsearch blood microparticlesearch cytosolsearch extracellular exosomesearch endocytic vesicle lumensearch nitric oxide transportsearch renal absorptionsearch positive regulation of cell deathsearch oxygen transportsearch oxidation-reduction processsearch small molecule metabolic processsearch receptor-mediated endocytosissearch response to hydrogen peroxidesearch protein heterooligomerizationsearch positive regulation of nitric oxide biosynthetic processsearch bicarbonate transportsearch regulation of blood vessel sizesearch hydrogen peroxide catabolic processsearch platelet aggregationsearch blood coagulationsearch transportsearch regulation of blood pressuresearch iron ion bindingsearch heme bindingsearch protein bindingsearch metal ion bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch oxygen bindingsearch hemoglobin bindingsearch peroxidase activitysearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch