2h35 Summary

pdbe.org/2h35
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Solution structure of Human normal adult hemoglobin

The structure was published by Xu, Y., Zheng, Y., Fan, J.S., and Yang, D., in 2006 in a paper entitled "A new strategy for structure determination of large proteins in solution without deuteration" (abstract).

The structure was determined using NMR spectroscopy and deposited in 2006.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha subunit and Hemoglobin beta subunit.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha subunit P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha subunit Not available
Homo sapienssearch 99% 141 100%
B Hemoglobin beta subunit P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta subunit P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha subunit Homo sapiens
P68871 (2 - 147) Hemoglobin beta subunit Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, C (P69905) extracellular regionsearch endocytic vesicle lumensearch cytosolsearch hemoglobin complexsearch extracellular vesicular exosomesearch membranesearch blood microparticlesearch cytosolic small ribosomal subunitsearch haptoglobin-hemoglobin complexsearch bicarbonate transportsearch protein heterooligomerizationsearch positive regulation of cell deathsearch oxygen transportsearch response to hydrogen peroxidesearch transportsearch oxidation-reduction processsearch small molecule metabolic processsearch hydrogen peroxide catabolic processsearch protein bindingsearch haptoglobin bindingsearch oxygen transporter activitysearch iron ion bindingsearch metal ion bindingsearch peroxidase activitysearch oxygen bindingsearch heme bindingsearch
B, D (P68871) hemoglobin complexsearch extracellular vesicular exosomesearch haptoglobin-hemoglobin complexsearch extracellular regionsearch blood microparticlesearch cytosolsearch endocytic vesicle lumensearch positive regulation of cell deathsearch oxygen transportsearch blood coagulationsearch small molecule metabolic processsearch positive regulation of nitric oxide biosynthetic processsearch response to hydrogen peroxidesearch bicarbonate transportsearch protein heterooligomerizationsearch regulation of blood pressuresearch platelet aggregationsearch hydrogen peroxide catabolic processsearch regulation of blood vessel sizesearch transportsearch renal absorptionsearch oxidation-reduction processsearch nitric oxide transportsearch protein bindingsearch oxygen transporter activitysearch iron ion bindingsearch oxygen bindingsearch haptoglobin bindingsearch metal ion bindingsearch peroxidase activitysearch hemoglobin bindingsearch heme bindingsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch