› 2h2t

X-ray diffraction
1.3Å resolution

CD23 Lectin domain, Calcium 2+-bound

Released:
DOI: 10.2210/pdb2h2t/pdb
PDB entry 2h2t coloured by chain, front view.
PDB entry 2h2t coloured by chain, side view.
PDB entry 2h2t coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural changes in the lectin domain of CD23, the low-affinity IgE receptor, upon calcium binding.
Wurzburg BA, Tarchevskaya SS, Jardetzky TS
Structure 14 1049-58 (2006)
PMID: 16765898

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139190 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Low affinity immunoglobulin epsilon Fc receptor soluble form Chain: B
Molecule details ›
Chain: B
Length: 175 amino acids
Theoretical weight: 19.52 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P06734 (Residues: 150-321; Coverage: 54%)
Gene names: CD23A, CLEC4J, FCE2, FCER2, IGEBF
Sequence domains: Lectin C-type domain
Structure domains: Mannose-Binding Protein A, subunit A

Ligands and Environments

1 bound ligand:
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 32-ID
Spacegroup: P212121
Unit cell:
a: 40.31Å b: 51.261Å c: 58.768Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.17 0.168 0.2
Expression system: Spodoptera frugiperda

Quick links

Citations

5 review citations

IgE in allergy and asthma today.
Gould et al. (2008)
4 more

5 mentions without citation

Computational and experimental prediction of human C-type lectin receptor druggability.
Aretz et al. (2014)
4 more