› 2h0k

X-ray diffraction
2.76Å resolution

Crystal Structure of a Mutant of Rat Annexin A5

Released:
DOI: 10.2210/pdb2h0k/pdb
PDB entry 2h0k coloured by chain, front view.
PDB entry 2h0k coloured by chain, side view.
PDB entry 2h0k coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Annexin-A5 assembled into two-dimensional arrays promotes cell membrane repair.
Bouter A, Gounou C, Bérat R, Tan S, Gallois B, Granier T, d'Estaintot BL, Pöschl E, Brachvogel B, Brisson AR
Nat Commun 2 270 (2011)
PMID: 21468022

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147017 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Annexin A5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 318 amino acids
Theoretical weight: 35.58 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P14668 (Residues: 2-319; Coverage: 100%)
Gene names: Anx5, Anxa5
Sequence domains: Annexin
Structure domains: Annexin

Ligands and Environments

1 bound ligand:
Ligand CA 22 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELLIOTT GX-21
Spacegroup: P21
Unit cell:
a: 51.108Å b: 67.184Å c: 112.313Å
α: 90° β: 94.79° γ: 90°
R-values:
R R work R free
0.201 0.197 0.261
Expression system: Escherichia coli

Quick links

Citations

44 review citations

Membrane Repair: Mechanisms and Pathophysiology.
Cooper et al. (2015)
43 more

2 mentions without citation

Annexin-A5 assembled into two-dimensional arrays promotes cell membrane repair.
Bouter et al. (2011)
1 more