2h07 Summary


crystal structure of human phosphoribosyl pyrophosphate synthetase 1 mutant S132A

The structure was published by Li, S., Lu, Y., Peng, B., and Ding, J., in 2007 in a paper entitled "Crystal structure of human phosphoribosylpyrophosphate synthetase 1 reveals a novel allosteric site" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.2 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Ribose-phosphate pyrophosphokinase I.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homohexamers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Ribose-phosphate pyrophosphokinase I P60891 (1-318) (PRPS1_HUMAN)search Homo sapienssearch 100% 326 94%
B Ribose-phosphate pyrophosphokinase I P60891 (1-318) (PRPS1_HUMAN)search Homo sapienssearch 100% 326 94%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P60891 (1 - 318) Ribose-phosphate pyrophosphokinase I Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (P60891) Rossmann foldsearch PF13793: N-terminal domain of ribose phosphate pyrophosphokinasesearch, PF14572: Phosphoribosyl synthetase-associated domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P60891) ribose phosphate diphosphokinase activitysearch protein homodimerization activitysearch metal ion bindingsearch ATP bindingsearch transferase activitysearch nucleotide bindingsearch magnesium ion bindingsearch kinase activitysearch cellular biosynthetic processsearch purine nucleotide biosynthetic processsearch pyrimidine nucleotide biosynthetic processsearch nervous system developmentsearch 5-phosphoribose 1-diphosphate biosynthetic processsearch carbohydrate metabolic processsearch nucleotide biosynthetic processsearch hypoxanthine biosynthetic processsearch pathogenesissearch purine nucleobase metabolic processsearch urate biosynthetic processsearch small molecule metabolic processsearch phosphorylationsearch ribonucleoside monophosphate biosynthetic processsearch cytosolsearch

Chain InterPro annotation
A, B Phosphoribosyl pyrophosphate synthetase, conserved sitesearch Ribose-phosphate diphosphokinasesearch Phosphoribosyltransferase-likesearch Ribose-phosphate pyrophosphokinase, N-terminal domainsearch