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crystal structure of human phosphoribosyl pyrophosphate synthetase 1 mutant S132A

X-ray diffraction
2.2Å resolution
PDB entry 2h07 coloured by chain, front view.
PDB entry 2h07 coloured by chain, side view.
PDB entry 2h07 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo hexamer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Ribose-phosphate pyrophosphokinase 1
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Multimeric state: homo hexamer
Accessible surface area: 59947.04 Å2
Buried surface area: 28691.25 Å2
Dissociation area: 7,595.77 Å2
Dissociation energy (ΔGdiss): 156.74 kcal/mol
Dissociation entropy (TΔSdiss): 31.43 kcal/mol
Symmetry number: 6
PDBe Complex ID: PDB-CPX-158121

Macromolecules

Ribose-phosphate pyrophosphokinase 1
Chains: A, B
Length: 326 amino acids
Theoretical weight: 35.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P60891 (Residues: 1-318; Coverage: 100%)
Gene name: PRPS1
Pfam:
InterPro:
CATH: Rossmann fold
Ribose-phosphate pyrophosphokinase 1 in PDB entry 2h07, assembly 1, front view.
Ribose-phosphate pyrophosphokinase 1 in PDB entry 2h07, assembly 1, side view.
Ribose-phosphate pyrophosphokinase 1 in PDB entry 2h07, assembly 1, top view.
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