2h02 Summary


Structural studies of protein tyrosine phosphatase beta catalytic domain in complex with inhibitors

The structure was published by Amarasinghe, K.K., Evdokimov, A.G., Xu, K., et al., Pokross, M.E., Gray, J.L., and Peters, K.G., in 2006 in a paper entitled "Design and synthesis of potent, non-peptidic inhibitors of HPTPbeta." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Protein tyrosine phosphatase, receptor type, B,.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Protein tyrosine phosphatase, receptor type, B, P23467 (1662-1973) (PTPRB_HUMAN)search Homo sapienssearch < 90% 313 90%
B Protein tyrosine phosphatase, receptor type, B, P23467 (1662-1973) (PTPRB_HUMAN)search Homo sapienssearch < 90% 313 90%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P23467 (1662 - 1973) Protein tyrosine phosphatase, receptor type, B, Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Protein tyrosine phosphatase superfamilysearch Protein-tyrosine phosphatasesearch

Chain ID Biological process (GO) Molecular function (GO)
A, B (P23467) dephosphorylationsearch protein dephosphorylationsearch phosphatase activitysearch protein tyrosine phosphatase activitysearch

Chain InterPro annotation
A, B Protein-tyrosine phosphatase, receptor/non-receptor typesearch Protein-tyrosine/Dual specificity phosphatasesearch Protein-tyrosine phosphatase, active sitesearch Protein-tyrosine phosphatase-likesearch