Function and Biology Details
Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- EGF-like domain
- Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
- Immunoglobulin-like fold
- Immunoglobulin-like domain superfamily
- Immunoglobulin-like domain
- Tyrosine-protein kinase, receptor Tie-2, Ig-like domain 1, N-terminal
- Fibrinogen, conserved site
- Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
1 more domain
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
Angiopoietin-2 and Angiopoietin-1 receptor (preferred)
PDBe Complex ID:
PDB-CPX-127304 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (4 distinct):
Angiopoietin-2
Molecule details ›
Chain: A
Length: 216 amino acids
Theoretical weight: 24.75 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Sequence domains: Fibrinogen beta and gamma chains, C-terminal globular domain
Structure domains:
Length: 216 amino acids
Theoretical weight: 24.75 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical:
O15123 (Residues: 281-495; Coverage: 45%)
Sequence domains: Fibrinogen beta and gamma chains, C-terminal globular domain
Structure domains:
Angiopoietin-1 receptor
Molecule details ›
Chain: B
Length: 423 amino acids
Theoretical weight: 47.19 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Sequence domains: Tie-2 Ig-like domain 1
Structure domains:
Length: 423 amino acids
Theoretical weight: 47.19 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical: Q02763 (Residues: 23-445; Coverage: 38%)
Sequence domains: Tie-2 Ig-like domain 1
Structure domains:
