› 2gx1

Solution NMR

Solution structure and alanine scan of a spider toxin that affects the activation of mammalian sodium channels

Released:
DOI: 10.2210/pdb2gx1/pdb
PDB entry 2gx1 coloured by chain, ensemble of 20 models, front view.
PDB entry 2gx1 coloured by chain, ensemble of 20 models, side view.
PDB entry 2gx1 coloured by chain, ensemble of 20 models, top view.
Source organism: Macrothele gigas
Primary publication:
Solution structure and alanine scan of a spider toxin that affects the activation of mammalian voltage-gated sodium channels.
Corzo G, Sabo JK, Bosmans F, Billen B, Villegas E, Tytgat J, Norton RS
J Biol Chem 282 4643-4652 (2007)
PMID: 17148449

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160709 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-hexatoxin-Mg1a Chain: A
Molecule details ›
Chain: A
Length: 29 amino acids
Theoretical weight: 3.3 KDa
Source organism: Macrothele gigas
Expression system: Not provided
UniProt:
  • Canonical: P83561 (Residues: 51-79; Coverage: 49%)
Sequence domains: Magi 5 toxic peptide family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

9 review citations

The hitchhiker's guide to the voltage-gated sodium channel galaxy.
Ahern et al. (2016)
8 more

1 mention without citation

Targeting voltage sensors in sodium channels with spider toxins.
Bosmans et al. (2010)