2gwx Summary



The structure was published by Xu, H.E., Lambert, M.H., Montana, V.G., et al., Willson, T.M., Kliewer, S.A., and Milburn, M.V., in 1999 in a paper entitled "Molecular recognition of fatty acids by peroxisome proliferator-activated receptors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 1999.

A re-refinement of this structure, using the same experimental data but carried out by different authors, is available as entry 2baw.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of PROTEIN (PPAR-DELTA).

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PROTEIN (PPAR-DELTA) Q03181 (175-441) (PPARD_HUMAN)search Homo sapienssearch < 90% 267 100%
B PROTEIN (PPAR-DELTA) Q03181 (175-441) (PPARD_HUMAN)search Homo sapienssearch < 90% 267 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q03181 (175 - 441) PROTEIN (PPAR-DELTA) Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (Q03181) DNA bindingsearch steroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitysearch nucleussearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch

Chain InterPro annotation
A, B Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Peroxisome proliferator-activated receptorsearch Peroxisome proliferator-activated receptor, betasearch Nuclear hormone receptor, ligand-bindingsearch