› 2gwx

X-ray diffraction
2.3Å resolution

MOLECULAR RECOGNITION OF FATTY ACIDS BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS

Released:
DOI: 10.2210/pdb2gwx/pdb
PDB entry 2gwx coloured by chain, front view.
PDB entry 2gwx coloured by chain, side view.
PDB entry 2gwx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular recognition of fatty acids by peroxisome proliferator-activated receptors.
Xu HE, Lambert MH, Montana VG, Parks DJ, Blanchard SG, Brown PJ, Sternbach DD, Lehmann JM, Wisely GB, Willson TM, Kliewer SA, Milburn MV
Mol Cell 3 397-403 (1999)
PMID: 10198642

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169863 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor delta Chains: A, B
Molecule details ›
Chains: A, B
Length: 267 amino acids
Theoretical weight: 30.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q03181 (Residues: 175-441; Coverage: 61%)
Gene names: NR1C2, PPARB, PPARD
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P21
Unit cell:
a: 39.772Å b: 94.222Å c: 96.701Å
α: 90° β: 97.77° γ: 90°
R-values:
R R work R free
0.246 0.246 0.288
Expression system: Escherichia coli

Quick links

Citations

211 review citations

The mechanisms of action of PPARs.
Berger et al. (2002)
210 more

3 mentions without citation

Limitations and lessons in the use of X-ray structural information in drug design.
Davis et al. (2008)
2 more