2gww Summary


Human vinculin (head domain, Vh1, residues 1-258) in complex with Shigella's IpaA vinculin binding site (residues 602-633)

The structure was published by Izard, T., Tran Van Nhieu, G., and Bois, P.R., in 2006 in a paper entitled "Shigella applies molecular mimicry to subvert vinculin and invade host cells." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.72 Å and deposited in 2006.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely vinculin and IpaA.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A vinculin P18206 (1-258) (VINC_HUMAN)search Homo sapienssearch 94% 266 97%
B IpaA P18010 (602-631) (IPAA_SHIFL)search Shigella flexnerisearch < 90% 30 73%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P18206 (1 - 258) vinculin Homo sapiens
P18010 (602 - 631) IpaA Shigella flexneri

Chain Structural classification (CATH) Sequence family (Pfam)
A (P18206) Four Helix Bundle (Hemerythrin (Met), subunit A)search PF01044: Vinculin familysearch
B Salmonella invasion protein Asearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P18206) structural molecule activitysearch cell adhesionsearch actin cytoskeletonsearch

Chain InterPro annotation
A Vinculin, conserved sitesearch Vinculin/alpha-cateninsearch Vinculinsearch
B Salmonella invasion protein Asearch