2gwo Summary

pdbe.org/2gwo
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crystal structure of TMDP

The structure was published by Kim, S.J., Jeong, D.G., Yoon, T.S., et al., Cho, S.K., Ryu, S.E., and Kim, J.H., in 2007 in a paper entitled "Crystal structure of human TMDP, a testis-specific dual specificity protein phosphatase: implications for substrate specificity" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Dual specificity protein phosphatase 13.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Dual specificity protein phosphatase 13 Q9UII6 (1-198) (DS13B_HUMAN)search Homo sapienssearch 100% 198 87%
B Dual specificity protein phosphatase 13 Q9UII6 (1-198) (DS13B_HUMAN)search Homo sapienssearch 100% 198 87%
C Dual specificity protein phosphatase 13 Q9UII6 (1-198) (DS13B_HUMAN)search Homo sapienssearch 100% 198 87%
D Dual specificity protein phosphatase 13 Q9UII6 (1-198) (DS13B_HUMAN)search Homo sapienssearch 100% 198 87%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q9UII6 (1 - 198) Dual specificity protein phosphatase 13 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B, C, D (Q9UII6) Protein tyrosine phosphatase superfamilysearch PF00782: Dual specificity phosphatase, catalytic domainsearch

Chain ID Biological process (GO) Molecular function (GO)
A, B, C, D (Q9UII6) protein dephosphorylationsearch dephosphorylationsearch peptidyl-tyrosine dephosphorylationsearch spermatogenesissearch meiotic nuclear divisionsearch protein tyrosine phosphatase activitysearch phosphoprotein phosphatase activitysearch protein tyrosine/serine/threonine phosphatase activitysearch phosphatase activitysearch hydrolase activitysearch

Chain InterPro annotation
A, B, C, D Dual specificity phosphatase, catalytic domainsearch Protein-tyrosine/Dual specificity phosphatasesearch Protein-tyrosine phosphatase, active sitesearch Atypical dual specificity phosphatase, subfamily Asearch Atypical dual specificity phosphatasesearch Dual specificity phosphatase, subgroup, catalytic domainsearch Dual specificity phosphatasesearch Protein-tyrosine phosphatase-likesearch