› 2gw5

X-ray diffraction
1.8Å resolution

Crystal Structure of LIR-2 (ILT4) at 1.8 : differences from LIR-1 (ILT2) in regions implicated in the binding of the Cytomegalovirus class I MHC homolog UL18

Released:
DOI: 10.2210/pdb2gw5/pdb
PDB entry 2gw5 coloured by chain, front view.
PDB entry 2gw5 coloured by chain, side view.
PDB entry 2gw5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of LIR-2 (ILT4) at 1.8 A: differences from LIR-1 (ILT2) in regions implicated in the binding of the Human Cytomegalovirus class I MHC homolog UL18.
Willcox BE, Thomas LM, Chapman TL, Heikema AP, West AP, Bjorkman PJ
BMC Struct Biol 2 6 (2002)
PMID: 12390682

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185380 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Leukocyte immunoglobulin-like receptor subfamily B member 2 Chain: A
Molecule details ›
Chain: A
Length: 197 amino acids
Theoretical weight: 21.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8N423 (Residues: 24-220; Coverage: 34%)
Gene names: ILT4, LILRB2, LIR2, MIR10
Sequence domains: Immunoglobulin domain
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand IPA 1 x IPA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P41212
Unit cell:
a: 62.53Å b: 62.53Å c: 106.917Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.242 0.24 0.279
Expression system: Escherichia coli

Quick links

Citations

9 review citations

The LILR family: modulators of innate and adaptive immune pathways in health and disease.
Brown et al. (2004)
8 more

9 mentions without citation

Structural insights into activation of antiviral NK cell responses.
Finton et al. (2012)
8 more