2gtn Summary


Mutated MAP kinase P38 (Mus Musculus) in complex with Inhbitor PG-951717

The structure was published by Sabat, M., Vanrens, J.C., Clark, M.P., et al., Walter, R.L., Mekel, M.J., and Janusz, M.J., in 2006 in a paper entitled "The development of novel C-2, C-8, and N-9 trisubstituted purines as inhibitors of TNF-alpha production." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier P47811 (MK14_MOUSE)search. The sample contained 348 residues which is 97% of the natural sequence. Out of 348 residues 336 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 P47811 (5-352) (MK14_MOUSE)search Mus musculussearch 97% 348 96%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P47811 (5 - 352) Mitogen-activated protein kinase 14 Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P47811) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P47811) cellular response to ionizing radiationsearch cellular response to lipopolysaccharidesearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch response to stresssearch protein phosphorylationsearch peptidyl-serine phosphorylationsearch phosphorylationsearch positive regulation of protein import into nucleussearch DNA damage checkpointsearch skeletal muscle tissue developmentsearch positive regulation of myotube differentiationsearch chondrocyte differentiationsearch regulation of transcription, DNA-templatedsearch cell morphogenesissearch positive regulation of myoblast fusionsearch fatty acid oxidationsearch transcription, DNA-templatedsearch stress-induced premature senescencesearch cellular response to vascular endothelial growth factor stimulussearch regulation of transcription from RNA polymerase II promotersearch positive regulation of transcription from RNA polymerase II promotersearch positive regulation of reactive oxygen species metabolic processsearch vascular endothelial growth factor receptor signaling pathwaysearch osteoclast differentiationsearch response to muramyl dipeptidesearch response to lipopolysaccharidesearch cartilage condensationsearch striated muscle cell differentiationsearch intracellular signal transductionsearch signal transduction in response to DNA damagesearch positive regulation of myoblast differentiationsearch p38MAPK cascadesearch glucose metabolic processsearch apoptotic processsearch negative regulation of canonical Wnt signaling pathwaysearch lipopolysaccharide-mediated signaling pathwaysearch cellular response to DNA damage stimulussearch myoblast differentiation involved in skeletal muscle regenerationsearch angiogenesissearch positive regulation of erythrocyte differentiationsearch cytosolsearch spindle polesearch nucleussearch cytoplasmsearch mitochondrionsearch cellsearch extracellular vesicular exosomesearch protein bindingsearch protein serine/threonine kinase activitysearch protein kinase activitysearch ATP bindingsearch MAP kinase activitysearch kinase activitysearch nucleotide bindingsearch NFAT protein bindingsearch transferase activity, transferring phosphorus-containing groupssearch transferase activitysearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch