2gtm Summary


Mutated Mouse P38 MAP Kinase Domain in complex with Inhibitor PG-892579

The structure was published by Sabat, M., Vanrens, J.C., Clark, M.P., et al., Walter, R.L., Mekel, M.J., and Janusz, M.J., in 2006 in a paper entitled "The development of novel C-2, C-8, and N-9 trisubstituted purines as inhibitors of TNF-alpha production." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier P47811 (MK14_MOUSE)search. The sample contained 348 residues which is 97% of the natural sequence. Out of 348 residues 340 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 P47811 (5-352) (MK14_MOUSE)search Mus musculussearch 97% 348 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P47811 (5 - 352) Mitogen-activated protein kinase 14 Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P47811) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P47811) protein phosphorylationsearch phosphorylationsearch positive regulation of erythrocyte differentiationsearch negative regulation of canonical Wnt signaling pathwaysearch positive regulation of protein import into nucleussearch cellular response to lipopolysaccharidesearch chondrocyte differentiationsearch DNA damage checkpointsearch cartilage condensationsearch response to lipopolysaccharidesearch apoptotic processsearch intracellular signal transductionsearch response to stresssearch stress-induced premature senescencesearch cellular response to vascular endothelial growth factor stimulussearch glucose metabolic processsearch vascular endothelial growth factor receptor signaling pathwaysearch angiogenesissearch peptidyl-serine phosphorylationsearch transcription, DNA-templatedsearch positive regulation of myoblast differentiationsearch positive regulation of transcription from RNA polymerase II promotersearch positive regulation of myoblast fusionsearch skeletal muscle tissue developmentsearch osteoclast differentiationsearch cell morphogenesissearch regulation of transcription, DNA-templatedsearch signal transduction in response to DNA damagesearch myoblast differentiation involved in skeletal muscle regenerationsearch cellular response to ionizing radiationsearch cellular response to DNA damage stimulussearch p38MAPK cascadesearch regulation of transcription from RNA polymerase II promotersearch striated muscle cell differentiationsearch positive regulation of reactive oxygen species metabolic processsearch fatty acid oxidationsearch response to muramyl dipeptidesearch positive regulation of myotube differentiationsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch lipopolysaccharide-mediated signaling pathwaysearch protein kinase activitysearch nucleotide bindingsearch protein bindingsearch transferase activitysearch MAP kinase activitysearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch kinase activitysearch NFAT protein bindingsearch nucleussearch spindle polesearch cytosolsearch cellsearch cytoplasmsearch mitochondrionsearch extracellular vesicular exosomesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch