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Mutated Mouse P38 MAP Kinase Domain in complex with Inhibitor PG-892579

X-ray diffraction
1.9Å resolution
PDB entry 2gtm coloured by chain, front view.
PDB entry 2gtm coloured by chain, side view.
PDB entry 2gtm coloured by chain, top view.
Source organism: Mus musculus
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Mitogen-activated protein kinase 14
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Multimeric state: monomeric
Accessible surface area: 16797.4 Å2
Buried surface area: 858.11 Å2
Dissociation area: 429.05 Å2
Dissociation energy (ΔGdiss): -1.76 kcal/mol
Dissociation entropy (TΔSdiss): 4.79 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-155650

Macromolecules

Mitogen-activated protein kinase 14
Chain: A
Length: 348 amino acids
Theoretical weight: 39.9 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P47811 (Residues: 5-352; Coverage: 97%)
Gene names: Crk1, Csbp1, Csbp2, Mapk14
Pfam: Protein kinase domain
InterPro:
CATH:
SCOP: Protein kinases, catalytic subunit
Mitogen-activated protein kinase 14 in PDB entry 2gtm, assembly 1, front view.
Mitogen-activated protein kinase 14 in PDB entry 2gtm, assembly 1, side view.
Mitogen-activated protein kinase 14 in PDB entry 2gtm, assembly 1, top view.
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