2gsf Summary


The Human Epha3 Receptor Tyrosine Kinase and Juxtamembrane Region

A publication describing this structure is not available. The depositing authors are Walker, J.R.search; Davis, T.search; Dong, A.search; Newman, E.M.search; MacKenzie, F.search; Weigelt, J.search; Sundstrom, M.search; Arrowsmith, C.H.search; Edwards, A.M.search; Bochkarev, A.search; Dhe-Paganon, S.search; Structural Genomics Consortium (SGC)search

This crystal structure was determined using X-ray diffraction at a resolution of 1.77 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Ephrin type-A receptor 3. This molecule has the UniProt identifier P29320 (EPHA3_HUMAN)search. The sample contained 373 residues which is < 90% of the natural sequence. Out of 373 residues 281 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Ephrin type-A receptor 3 P29320 (577-947) (EPHA3_HUMAN)search Homo sapienssearch < 90% 373 75%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P29320 (577 - 947) Ephrin type-A receptor 3 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search SAM domain (Sterile alpha motif)search, Protein tyrosine kinasesearch, Ephrin type-A receptor 2 transmembrane domainsearch

Chain ID Biological process (GO) Molecular function (GO)
A (P29320) protein phosphorylationsearch transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein kinase activitysearch protein tyrosine kinase activitysearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch Ephrin receptor, transmembrane domainsearch