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CRYSTAL STRUCTURE OF GLUTAMATE-1-SEMIALDEHYDE AMINOMUTASE (AMINOTRANSFERASE, WILD-TYPE FORM)

Source organism: Synechococcus sp.
Biochemical function: glutamate-1-semialdehyde 2,1-aminomutase activity
Biological process: tetrapyrrole biosynthetic process
Cellular component: cytoplasm

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EC 5.4.3.8: Glutamate-1-semialdehyde 2,1-aminomutase

Reaction catalysed:
(S)-4-amino-5-oxopentanoate = 5-aminolevulinate
Systematic name:
(S)-4-amino-5-oxopentanoate 4,5-aminomutase
Alternative Name(s):
  • Glutamate-1-semialdehyde aminotransferase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00202
Domain description: Aminotransferase class-III
Occurring in:
  1. Glutamate-1-semialdehyde 2,1-aminomutase
The deposited structure of PDB entry 2gsa contains 2 copies of Pfam domain PF00202 (Aminotransferase class-III) in Glutamate-1-semialdehyde 2,1-aminomutase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR005814
Domain description: Aminotransferase class-III
Occurring in:
  1. Glutamate-1-semialdehyde 2,1-aminomutase
IPR004639
Domain description: Tetrapyrrole biosynthesis, glutamate-1-semialdehyde aminotransferase
Occurring in:
  1. Glutamate-1-semialdehyde 2,1-aminomutase
IPR015421
Domain description: Pyridoxal phosphate-dependent transferase, major domain
Occurring in:
  1. Glutamate-1-semialdehyde 2,1-aminomutase
IPR015422
Domain description: Pyridoxal phosphate-dependent transferase, small domain
Occurring in:
  1. Glutamate-1-semialdehyde 2,1-aminomutase
IPR015424
Domain description: Pyridoxal phosphate-dependent transferase
Occurring in:
  1. Glutamate-1-semialdehyde 2,1-aminomutase

Structure domains

CATH CATH domains
3.90.1150.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Aspartate Aminotransferase, domain 1
Homology: Aspartate Aminotransferase, domain 1
Occurring in:
  1. Glutamate-1-semialdehyde 2,1-aminomutase
The deposited structure of PDB entry 2gsa contains 2 copies of CATH domain 3.90.1150.10 (Aspartate Aminotransferase, domain 1) in Glutamate-1-semialdehyde 2,1-aminomutase. Showing 1 copy in chain A.
3.40.640.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Aspartate Aminotransferase; domain 2
Homology: Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Occurring in:
  1. Glutamate-1-semialdehyde 2,1-aminomutase
The deposited structure of PDB entry 2gsa contains 2 copies of CATH domain 3.40.640.10 (Aspartate Aminotransferase; domain 2) in Glutamate-1-semialdehyde 2,1-aminomutase. Showing 1 copy in chain A.
SCOP SCOP annotation
53417
Class: Alpha and beta proteins (a/b)
Fold: PLP-dependent transferase-like
Superfamily: PLP-dependent transferases
Occurring in:
  1. Glutamate-1-semialdehyde 2,1-aminomutase
The deposited structure of PDB entry 2gsa contains 2 copies of SCOP domain 53417 (GABA-aminotransferase-like) in Glutamate-1-semialdehyde 2,1-aminomutase. Showing 1 copy in chain A.

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