Crystal Structure of the active EGFR kinase domain
The structure was published by Zhang, X., Gureasko, J., Shen, K., Cole, P.A., and Kuriyan, J., in 2006 in a paper entitled "An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2006.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Epidermal growth factor receptor. This molecule has the UniProt identifier P00533 (EGFR_HUMAN). The sample contained 330 residues which is < 90% of the natural sequence. Out of 330 residues 303 were observed and are deposited in the PDB.
The molecule most likely forms homodimers.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: