2gqg Summary

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X-ray Crystal Structure of Dasatinib (BMS-354825) Bound to Activated ABL Kinase Domain

The structure was published by Tokarski, J.S., Newitt, J., Chang, C.Y.J., et al., Xie, D., Zhang, Y., and Klei, H.E., in 2006 in a paper entitled "The Structure of Dasatinib (BMS-354825) Bound to Activated ABL Kinase Domain Elucidates Its Inhibitory Activity against Imatinib-Resistant ABL Mutants" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Proto-oncogene tyrosine-protein kinase ABL1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Proto-oncogene tyrosine-protein kinase ABL1 P00519 (229-500) (ABL1_HUMAN)search Homo sapienssearch < 90% 278 100%
B Proto-oncogene tyrosine-protein kinase ABL1 P00519 (229-500) (ABL1_HUMAN)search Homo sapienssearch < 90% 278 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00519 (229 - 500) Proto-oncogene tyrosine-protein kinase ABL1 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Biological process (GO) Molecular function (GO)
A, B (P00519) protein phosphorylationsearch ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein tyrosine kinase activitysearch protein kinase activitysearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch