2gpo Summary


Estrogen Related Receptor-gamma ligand binding domain complexed with a synthetic peptide from RIP140

The structure was published by Wang, L., Zuercher, W.J., Consler, T.G., et al., McKee, D.D., Willson, T.M., and Nolte, R.T., in 2006 in a paper entitled "X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.95 Å and deposited in 2006.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Estrogen-related receptor gamma and Nuclear receptor-interacting protein 1.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Estrogen-related receptor gamma P62508 (229-458) (ERR3_HUMAN)search Homo sapienssearch < 90% 230 97%
C Nuclear receptor-interacting protein 1 P48552 (366-390) (NRIP1_HUMAN)search Homo sapienssearch < 90% 25 40%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P62508 (229 - 458) Estrogen-related receptor gamma Homo sapiens
P48552 (366 - 390) Nuclear receptor-interacting protein 1

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P62508) sequence-specific DNA binding transcription factor activitysearch steroid hormone receptor activitysearch DNA bindingsearch nucleussearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch

Chain InterPro annotation
A Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch